Analysis in spontaneously hypertensive rats

被引：4

作者：

Nara, Y

Mashimo, T

Tamada, T

Matsumoto, C

Ishinaga, Y

Nabika, T

Ikeda, K

Sawamura, M

Yamori, Y

机构：

[1] Univ E Asia, Grad Sch Integrated Sci & Art, Shimonoseki, Yamaguchi 7518503, Japan

[2] Kyoto Univ, Grad Sch Human & Environm Studies, Kyoto, Japan

[3] Shimane Med Univ, Matsue, Shimane, Japan

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1999年 / 26卷 / 07期

关键词：

hypertension; linkage analysis; microsatellite; salt sensitivity; stroke-prone spontaneously hypertensive rats; Wistar-Kyoto rat;

D O I：

10.1046/j.1440-1681.1999.03089.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Linkage analysis is performed between basal or salt-sensitive high blood pressure and several loci on chromosomes in F2 progenies obtained from crossing stroke-prone spontaneously hypertensive rats (SBR) and normotensive Wistar-Kyoto rats. 2. Basal hypertensive genes are mapped to a region near the D1Mit2 locus on chromosome 1 and near the D3Mgh8 locus on chromosome 3 in the male and female F2 progenies. 3. Salt-sensitive hypertensive gene is mapped to a region near RR1023 locus on chromosome 10 in the male F2 progenies. 4. Salt-sensitive hypertensive gene is mapped to a region near D3Mgh12 locus on chromosome 3 in the female F2 progenies.

引用

页码：536 / 538

页数：3

共 18 条

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CICILA GT, 1994, J HYPERTENS, V12, P643

[2] CHROMOSOMAL MAPPING OF 2 GENETIC-LOCI ASSOCIATED WITH BLOOD-PRESSURE REGULATION IN HEREDITARY HYPERTENSIVE RATS [J].