CD40-mediated activation of the NF-κB2 pathway

被引:52
作者
Hostager, Bruce S. [1 ,2 ]
Bishop, Gail A. [2 ,3 ,4 ,5 ]
机构
[1] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA
[2] Univ Iowa, Grad Program Immunol, Iowa City, IA 52242 USA
[3] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
[4] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA
[5] Iowa City VA Med Ctr, Iowa City, IA USA
关键词
CD40; NF-kappa B; signal transduction; KAPPA-B ACTIVATION; KINASE; CELLS; EXPRESSION; TRAF2;
D O I
10.3389/fimmu.2013.00376
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
CD40 is a critical stimulatory receptor on antigen-presenting cells of the immune system. CD40-mediated activation of B cells is particularly important for normal humoral immune function. Engagement of CD40 by its ligand, CD154, on the surface of activated T cells initiates a variety of signals in B cells including the activation of MAP kinases and NE-kappa B. The transcriptional regulator NE-kappa B is in reality a family of factors that can promote B cell activation, differentiation, and proliferation. Complex and only partially understood biochemical mechanisms allow CD40 to trigger two distinct NE-kappa B activation pathways resulting in the activation of canonical (NF-kappa B1) and non-canonical (NF-kappa B2) NF-kappa B. This brief review provides a summary of mechanisms responsible for activation of the latter, which appears to be particularly important for enhancing the viability of B cells at various stages in their life cycle and may also contribute to the development of B cell malignancies. CD40 is also expressed by various cell types in addition to B cells, including T cells, macrophages, dendritic cells, as well as certain non-hematopoietic cells. Here too, while perhaps less extensively studied than in B cells, the CD40-mediated activation of NF-kappa B2 also appears to have important roles in cellular physiology.
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页数:4
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