Molecular mechanisms of the PRL phosphatases

被引：93

作者：

Rios, Pablo ^{[1
]}

Li, Xun ^{[1
]}

Koehn, Maja ^{[1
]}

机构：

[1] European Mol Biol Lab, Genome Biol Unit, D-69117 Heidelberg, Germany

来源：

FEBS JOURNAL | 2013年 / 280卷 / 02期

关键词：

cancer; cell signalling; dual specificity phosphatases; metastasis; phosphatase of regenerating liver; protein phosphatases; PROTEIN-TYROSINE-PHOSPHATASE; DUAL-SPECIFICITY PHOSPHATASE; EPITHELIAL-MESENCHYMAL TRANSITION; VOLTAGE-SENSING PHOSPHATASE; GTPASE-ACTIVATING PROTEIN; REGENERATING LIVER; COLORECTAL-CANCER; PHOSPHOINOSITIDE PHOSPHATASE; CRYSTAL-STRUCTURE; TUMOR-SUPPRESSOR;

D O I：

10.1111/j.1742-4658.2012.08565.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The phosphatases of regenerating liver (PRLs) are an intriguing family of dual specificity phosphatases due to their oncogenicity. The three members are small, single domain enzymes. We provide an overview of the phosphatases of regenerating liver, compare them to related phosphatases, and review recent reports about each phosphatase. Finally, we discuss similarities and differences between the phosphatases of regenerating liver, focusing on their molecular mechanisms and signalling pathways.

引用

页码：505 / 524

页数：20

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