Dynamics of West Nile virus evolution in mosquito vectors

被引:33
作者
Grubaugh, Nathan D. [1 ,2 ]
Ebel, Gregory D. [1 ]
机构
[1] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA
[2] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
关键词
CULEX-PIPIENS; AEDES-AEGYPTI; COOPERATIVE INTERACTIONS; ARBOVIRUS INFECTION; PURIFYING SELECTION; MUTANT SPECTRUM; RNA VIRUSES; FITNESS; HOST; DIVERSITY;
D O I
10.1016/j.coviro.2016.09.007
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
West Nile virus remains the most common cause of arboviral encephalitis in North America. Since it was introduced, it has undergone adaptive genetic change as it spread throughout the continent. The WNV transmission cycle is relatively tractable in the laboratory. Thus the virus serves as a convenient model system for studying the population biology of mosquito-borne flaviviruses as they undergo transmission to and from mosquitoes and vertebrates. This review summarizes the current knowledge regarding the population dynamics of this virus within mosquito vectors.
引用
收藏
页码:132 / 138
页数:7
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