The Role of Galectin-3 in Stellate Cell Activation and Liver Fibrosis

被引：0

作者：

Jiang, Joy X. ^{[1
]}

Chen, Xiangling ^{[1
]}

Fukada, Hiroo ^{[1
]}

Hsu, Dan K. ^{[2
]}

Liu, Fu-tong ^{[2
]}

Toeroek, Natalie J. ^{[1
]}

机构：

[1] UC Davis Med Ctr, Div Gastroenterol & Hepatol, Dept Internal Med, 4635 2nd Ave,Suite 1001, Sacramento, CA 95817 USA

[2] UC Davis Med Ctr, Dept Dermatol, Sacramento, CA 95817 USA

来源：

GALECTINS AND DISEASE IMPLICATIONS FOR TARGETED THERAPEUTICS | 2012年 / 1115卷

关键词：

GROWTH-FACTOR-BETA; APOPTOTIC BODIES; PHAGOCYTOSIS; PROLIFERATION; MOLECULE; ADHESION; OXIDASE;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gal3 (galectin-3) has been known to be involved in the regulation of kidney, lung and liver fibrosis. We have reported a novel mechanism by which Gal3 contributes to fibrogenesis. Extracellular Gal3 is required for tethering of apoptotic bodies by HSC via cross-linking with integrin alpha v beta 3, and consequently promoting HSC activation. On the other hand, phagocytosis induces Gal3 production by both HSC and Kupffer cells. Taken together, Gal3 may become a therapeutic target for antifibrogenic strategy.

引用

页码：391 / +

页数：3

共 50 条

[21] The role of Galectin-3 in a-synuclein-induced microglial activation
Boza-Serrano, Antonio
Reyes, Juan F.
Rey, Nolwen L.
Leffler, Hakon
Bousset, Luc
Nilsson, Ulf
Brundin, Patrik
Venero, Jose Luis
Burguillos, Miguel Angel
Deierborg, Tomas
ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2014, 2
[22] Hyperglycemia and Hyperinsulinemia Promote Pancreatic Stellate Cells Activation and Galectin-3 Expression: Potential Role in Pancreatic Cancer Development
Li, L.
Waldron, R. T.
Lugea, A.
Pandol, S. J.
PANCREAS, 2013, 42 (08) : 1362 - 1363
[23] The role of Fyn in hepatic stellate cells activation and liver fibrosis
Lu, Yin Ying
Rong, Guanghua
Feng, Dechun
Wang, Chunping
Chang, Xiujuan
Gao, Xudong
Chen, Yan
Qu, Jianhui
Zeng, Zhen
Wang, Hong
Gao, Bin
Yang, Yongping
HEPATOLOGY, 2014, 60 : 566A - 566A
[24] Unraveling the pathophysiologic role of galectin-3 in chronically injured liver
Ezhilarasan, Devaraj
JOURNAL OF CELLULAR PHYSIOLOGY, 2023, 238 (04) : 673 - 686
[25] The role of galectin-3 in bone
Maupin, Kevin A.
Wang, John L.
Williams, Bart O.
GLYCOBIOLOGY, 2013, 23 (11) : 1381 - 1381
[26] The role of galectin-3 in asthma
Sammut, D.
Haitchi, H. M.
Lau, L.
Wilson, S.
Holloway, J.
Davies, D.
Howarth, P. H.
THORAX, 2007, 62 : A59 - A60
[27] The Role of Galectin-3 in the Kidneys
Chen, Szu-Chia
Kuo, Po-Lin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (04)
[28] Galectin-1 promotes the activation of hepatic stellate cell and liver fibrosis through glycosylation-dependent interactions
Wu, Ming-Heng
HEPATOLOGY, 2015, 62 : 895A - 895A
[29] Epigenetic regulation of hepatic stellate cell activation and liver fibrosis
El Taghdouini, Adil
van Grunsven, Leo A.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 2016, 10 (12) : 1397 - 1408
[30] Design and Synthesis of Dual Galectin-3 and EGFR Inhibitors Against Liver Fibrosis
Liu, Shuanglin
He, Fei
Jin, Can
Li, Qing
Zhao, Guilong
Ding, Kan
CHEMISTRY-AN ASIAN JOURNAL, 2025, 20 (02)

← 1 2 3 4 5 →