Immunohistochemical study of pepsinogen C expression in cutaneous malignant melanoma:: association with clinicopathological parameters

被引:8
作者
Quintela, I
Vizoso, F
Serra, C
González, LO
Fernández, R
Merino, AM
Baltasar, A
机构
[1] Hosp Jove, Dept Gen Surg, Gijon 33290, Asturias, Spain
[2] Hosp Virgen Lirios, Dept Gen Surg, Alicante, Spain
[3] Hosp Jove, Dept Pathol, Gijon, Asturias, Spain
关键词
melanoma; pepsinogen c; androgen receptor; prognosis;
D O I
10.1177/172460080101600403
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background: The aim of this study was to evaluate the pepsinogen C expression in malignant cutaneous melanomas and analyze its possible relationship to clinical and pathological parameters. Pepsinogen C is an aspartyl proteinase primarily involved in the digestion of proteins in the stomach and represents one of the main androgen-inducible proteins in breast cancer cells. Method: Tumoral pepsinogen C expression was retrospectively analyzed in 35 paraffin-embedded tissues from patients with primary malignant cutaneous melanoma and in 10 samples from 10 benign lesions (4 dermal melanocytic nevi, 4 compound melanocytic nevi and 2 dysplastic melanocytic nevi), using immunohistochemical methods. Results: The benign lesions were consistently negative for pepsinogen C, whereas 20 of the 35 malignant melanomas (57%) showed positive immunostaining for pepsinogen C. The percentage of pepsinogen C-positive tumors was significantly higher in men than in women (p=0.01) and in epithelioid melanomas than in fusocellular or mixed type melanomas (P=0.003). In addition, the percentage of pepsinogen-C positive tumors was positively and significantly correlated with lesion thickness (p=0.003), Clark's level of invasion (p=0.028) and tumor stage (p<0.001). Conclusion: Pepsinogen C could be a new prognosticator of unfavorable outcome in cutaneous malignant melanoma.
引用
收藏
页码:240 / 244
页数:5
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