Effects of electronic cigarette on platelet and vascular function after four months of use

被引：25

作者：

Ikonomidis, Ignatios ^{[1
,2
]}

Katogiannis, Konstantinos ^{[1
,2
]}

Kostelli, Gavriella ^{[1
,2
]}

Kourea, Kallirhoe ^{[1
,2
]}

Kyriakou, Elias ^{[3
,4
]}

Kypraiou, Athina ^{[3
,4
]}

Tsoumani, Maria ^{[5
]}

Andreadou, Ioanna ^{[5
]}

Lambadiari, Vaia ^{[1
,2
]}

Plotas, Panagiotis ^{[1
,2
]}

Thymis, Ioannis ^{[1
,2
]}

Tsantes, Argirios E. ^{[3
,4
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Med Sch, Cardiol Dept 2,Lab Prevent Cardiol, Athens, Greece

[2] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Med Sch, Cardiol Dept 2,Smoking Cessat Clin, Athens, Greece

[3] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Sch Med, Lab Haematol, Athens, Greece

[4] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Sch Med, Blood Bank Unit, Athens, Greece

[5] Natl & Kapodistrian Univ Athens, Sch Pharm, Dept Pharmaceut Chem, Athens, Greece

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2020年 / 141卷

关键词：

Electronic cigarette; Platelets; Light transmission aggregometry; PFA-100; Pulse wave velocity; Oxidative stress; OXIDATIVE STRESS; ARTERIAL STIFFNESS; SMOKING; NICOTINE; MAINSTREAM; DISEASE;

D O I：

10.1016/j.fct.2020.111389

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

We examined the effects of electronic cigarette on platelet and vascular function after 4 months of use compared to tobacco smoking. Forty smokers without cardiovascular disease were randomized to smoke either conventional cigarettes or an electronic cigarette (nicotine concentration of 12 mg/ml). At baseline and after four months, we measured a) platelet function by Platelet Function Analyzer PFA-100 and Light Transmission Aggregometry, b) pulse wave velocity, c) plasma malondialdehyde levels as oxidative stress index and d) the exhaled CO level. After 4 months, continuation of conventional cigarette smoking further impaired platelet function compared to vaping as assessed by PFA (mean increase 27.1 vs 11.6 s, p for interaction = 0.048) and by LTA (decline 24.1 vs 9.4%, p for interaction = 0.045). Conversely, compared to smoking, vaping resulted in greater reduction of exhaled CO (6.9 ppm vs 2.6, p for interaction < 0.001), improvement of PWV (decrease of 0.8 m/s vs increase of 0.8 m/s, p for interaction = 0.020) and reduction of MDA (reduction 0.13 vs increase 0.19 nmol/L, p for interaction = 0.035). Switching to electronic cigarette for 4 months has a neutral effect on platelet function while it reduces arterial stiffness and oxidative stress compared to tobacco smoking.

引用

页数：5

共 23 条

[1] The pathophysiology of cigarette C-V smoking and cardiovascular disease - An update [J].