Enantiopure 2-Substituted Glyceraidehyde Derivatives by Aza-Claisen Rearrangement or C-Alkylation of Enamines

被引：6

作者：

Bridgwood, Katy L. ^{[1
]}

Tzschucke, C. Christoph ^{[1
]}

O'Brien, Matthew ^{[1
]}

Wittrock, Sven ^{[1
]}

Goodman, Jonathan M. ^{[1
]}

Davies, John E. ^{[1
]}

Logan, Angus W. J. ^{[1
]}

Huettl, Matthias R. M. ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 20期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ol8018242

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Alkyl derivatives of butane-2,3-diacetal (BDA) protected glyceraldehyde were stereoselectively prepared by aza-Claisen rearrangement of N-allyl-enammonium ions or C-alkylation of enamines. This allows rapid and convenient access to densely functionalized chiral building blocks.

引用

页码：4537 / 4540

页数：4

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