Local streamline generation by mechanical oscillation in a microfluidic chip for noncontact cell manipulations

被引：63

作者：

Hagiwara, Masaya ^{[1
]}

Kawahara, Tomohiro ^{[2
,3
]}

Arai, Fumihito ^{[4
]}

机构：

[1] Univ Calif Los Angeles, Aerosp & Mech Engn Dept, Los Angeles, CA 90095 USA

[2] Kyushu Inst Technol, Kitakyushu, Fukuoka 8080196, Japan

[3] MIT, Cambridge, MA 02139 USA

[4] Nagoya Univ, Dept Micronano Syst Engn, Nagoya, Aichi 4648603, Japan

来源：

APPLIED PHYSICS LETTERS | 2012年 / 101卷 / 07期

基金：

日本学术振兴会;

关键词：

CIRCULAR-CYLINDER; TERM; FLOW;

D O I：

10.1063/1.4746247

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

This paper presents a method to manipulate cells in a microfluidic chip without contact. A local streamline is generated when high-frequency oscillation of the microtool is induced in a microfluidic chip. The streamline can be controlled by tuning the oscillation parameters of the tool, such as the amplitude and phase of the oscillation. Cells then flow in the microchannel in accordance with the streamline, and their position, posture, and trajectories are controlled. Bovine oocyte manipulations, which were attraction, repulsion, and rotation, were conducted to demonstrate the capability of the proposed method without any contact by the oscillation tool. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4746247]

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