COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection

被引：143

作者：

Chi, Wei-Yu ^{[1
]}

Li, Yen-Der ^{[2
]}

Huang, Hsin-Che ^{[3
]}

Chan, Timothy En Haw ^{[4
,5
,6
]}

Chow, Sih-Yao ^{[7
]}

Su, Jun-Han ^{[2
]}

Ferrall, Louise ^{[8
]}

Hung, Chien-Fu ^{[8
,9
,10
]}

Wu, T-C ^{[8
,9
,10
,11
,12
]}

机构：

[1] Weill Cornell Med, Physiol Biophys & Syst Biol Grad Program, New York, NY USA

[2] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[3] Mem Sloan Kettering Canc Ctr, Triinst PhD Program Chem Biol, 1275 York Ave, New York, NY 10021 USA

[4] Max Planck Inst Immunobiol & Epigenet, Int Max Planck Res Sch Immunobiol Epigenet & Meta, Freiburg, Germany

[5] Univ Freiburg, Med Ctr, Dept Urol, Freiburg, Germany

[6] Univ Freiburg, Fac Biol, Freiburg, Germany

[7] EirGenix Inc, Downstream Proc Sci, Hsinchu, Taiwan

[8] Johns Hopkins Univ, Dept Pathol, Baltimore, MD 21218 USA

[9] Johns Hopkins Univ, Dept Oncol, Baltimore, MD 21218 USA

[10] Johns Hopkins Univ, Dept Obstet & Gynecol, Baltimore, MD 21218 USA

[11] Johns Hopkins Univ, Dept Microbiol & Immunol, Baltimore, MD 21218 USA

[12] Johns Hopkins Med Inst, CRB 2 Room 309,1550 Orleans St, Baltimore, MD 21231 USA

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2022年 / 29卷 / 01期

关键词：

COVID-19; Vaccine; Immunity; Variant; SARS-CoV-2; MESSENGER-RNA; BNT162B2; VACCINE; CHADOX1; NCOV-19; NEUTRALIZING ANTIBODY; OMICRON VARIANT; NON-INFERIORITY; UNITED-STATES; SINGLE-BLIND; IMMUNOGENICITY; SAFETY;

D O I：

10.1186/s12929-022-00853-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Coronavirus Disease 2019 (COVID-19) has been the most severe public health challenge in this century. Two years after its emergence, the rapid development and deployment of effective COVID-19 vaccines have successfully controlled this pandemic and greatly reduced the risk of severe illness and death associated with COVID-19. However, due to its ability to rapidly evolve, the SARS-CoV-2 virus may never be eradicated, and there are many important new topics to work on if we need to live with this virus for a long time. To this end, we hope to provide essential knowledge for researchers who work on the improvement of future COVID-19 vaccines. In this review, we provided an up-to-date summary for current COVID-19 vaccines, discussed the biological basis and clinical impact of SARS-CoV-2 variants and subvariants, and analyzed the effectiveness of various vaccine booster regimens against different SARS-CoV-2 strains. Additionally, we reviewed potential mechanisms of vaccine-induced severe adverse events, summarized current studies regarding immune correlates of protection, and finally, discussed the development of next-generation vaccines.

引用

页数：27

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