Synthesis of 5-radioiodoarabinosyl uridine analog for probing the HSV-1 thymidine kinase gene

被引：3
作者：
Lin, Kun-I [1 ,2 ]
Chiang, Li-Wu [1 ]
Wu, Chien-Hung [1 ]
Chen, Shao-Wei [1 ]
Yu, Chung-Shan [1 ]
机构：
[1] Natl Tsing Hua Univ, Dept Nucl Sci, Hsinchu 300, Taiwan
[2] Chang Bing Mem Hosp, Changhua 505, Chang Hua Cty, Taiwan
来源：
JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2007年 / 54卷 / 02期
关键词：
HSV-1; TK; cancer; arabinosyl uridine; stannane; radioiodine;
D O I：
10.1002/jccs.200700080
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tumor cells transduced with herpes simplex virus thymidine kinase gene have been intensively applied to the field of positron emission tomography via imaging of its substrate. As a pilot synthesis approach, a facile preparation of 5-[I-125]iodoarabinosyl uridine starting from commercially available uridine is reported herein.
引用
收藏
页码：563 / 568
页数：6
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