GATA Transcription Factors in the Developing Reproductive System

被引：30
作者：
Zaytouni, Tamara [1 ]
Efimenko, Evgeni E. [1 ]
Tevosian, Sergei G. [1 ]
机构：
[1] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Genet, Hanover, NH 03756 USA
来源：
ADVANCES IN GENETICS, VOL 76 | 2011年 / 76卷
关键词：
MULLERIAN-INHIBITING SUBSTANCE; PRIMORDIAL GERM-CELLS; PERITUBULAR MYOID CELLS; TESTIS CORD FORMATION; ZINC-FINGER PROTEIN; SEX DETERMINATION REVEALS; STEROIDOGENIC FACTOR-I; SIDE-CHAIN CLEAVAGE; BETA-CATENIN; SERTOLI-CELLS;
D O I：
10.1016/B978-0-12-386481-9.00004-3
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Previous work has firmly established the role for both GATA4 and FOG2 in the initial global commitment to sexual fate, but their (joint or individual) function in subsequent steps remained unknown. Hence, gonad-specific deletions of these genes in mice were required to reveal their roles in sexual development and gene regulation. The development of tissue-specific Cre lines allowed for substantial advances in the understanding of the function of GATA proteins in sex determination, gonadal differentiation and reproductive development in mice. Here we summarize the recent work that examined the requirement of GATA4 and FOG2 proteins at several critical stages in testis and ovarian differentiation. We also discuss the molecular mechanisms involved in this regulation through the control of Dmrt1 gene expression in the testis and the canonical Wnt/beta-catenin pathway in the ovary. (C) 2011, Elsevier Inc.
引用
收藏
页码：93 / 134
页数：42
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