A role of ghrelin in cancerogenesis

被引：17

作者：

Majchrzak, K. ^{[1
]}

Szyszko, K. ^{[1
]}

Pawlowski, K. M. ^{[1
,2
]}

Motyl, T. ^{[1
]}

Krol, M. ^{[1
]}

机构：

[1] WULS, Fac Vet Med, Dept Physiol Sci, PL-02776 Warsaw, Poland

[2] WULS, Fac Anim Sci, Dept Anim Environm Biol, PL-02786 Warsaw, Poland

来源：

POLISH JOURNAL OF VETERINARY SCIENCES | 2012年 / 15卷 / 01期

关键词：

ghrelin; growth hormone secretagogue receptor; cancer; canine mammary cancer; HORMONE SECRETAGOGUE RECEPTOR; ACTIVATED PROTEIN-KINASE; CULTURED ADENOHYPOPHYSEAL CELLS; DES-ACYL GHRELIN; FOOD-INTAKE; PREPROGHRELIN ISOFORM; BIOLOGICAL-ACTIVITY; PITUITARY-ADENOMAS; ENDOGENOUS LIGAND; ENDOCRINE TUMORS;

D O I：

10.2478/v10181-011-0133-5

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Ghrelin is a 28 amino-acid multi-functional peptide hormone, which was identified as a natural ligand of the growth hormone secretagogue receptor (GHS-R). Pituitary growth hormone-releasing activity in both animals and humans has been well documented. It has various biological functions, including regulation of appetite and body weight, control of energy homeostasis, modulation of cardiovascular and gastrointestinal system and anti-inflammatory effect. However, both ghrelin and its receptor (GHS-R) are widely distributed in various tumors, which strongly implies their role in neoplastic cell growth trough autocrine/paracrine mechanism. Multiple studies have demonstrated the role of ghrelin in cancer cells proliferation, differentiation, invasiveness and apoptosis inhibition. The ghrelin axis is more complex than it was originally thought and consist of several compounds that might interact with each other and affect ghrelin activities. Here, we provide an overview of the ghrelin and its receptor role in tumor progression.

引用

页码：189 / 197

页数：9

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