Functional Impact of Autophagy-Related Genes on the Homeostasis and Dynamics of Pancreatic Cancer Cell Lines

被引：4

作者：

Mazza, Tommaso ^{[1
]}

Fusilli, Caterina ^{[1
]}

Saracino, Chiara ^{[2
]}

Mazzoccoli, Gianluigi ^{[3
]}

Tavano, Francesca ^{[2
]}

Vinciguerra, Manlio ^{[2
]}

Pazienza, Valerio ^{[2
]}

机构：

[1] IRCCS Casa Sollievo Sofferenza Mendel, Bioinformat Unit, I-00198 Rome, Italy

[2] IRCCS Casa Sollievo Sofferenza, Gastroenterol Unit, I-71013 San Giovanni Rotondo, TG, Italy

[3] IRCCS Casa Sollievo Sofferenza, Div Internal Med, I-71013 San Giovanni Rotondo, TG, Italy

来源：

IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS | 2015年 / 12卷 / 03期

关键词：

Autophagy; network topology; pancreatic cancer; starvation; TUMOR-SUPPRESSOR GENE; REGULATES AUTOPHAGY; PROTEIN; GEMCITABINE; EXPRESSION; AMBRA1; DEATH; INHIBITION; PHENOTYPE; APOPTOSIS;

D O I：

10.1109/TCBB.2014.2371824

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Pancreatic cancer is a highly aggressive and chemotherapy-resistant malignant neoplasm. In basal condition, it is characterized by elevated autophagy activity, which is required for tumor growth and that correlates with treatment failure. We analyzed the expression of autophagy related genes in different pancreatic cancer cell lines. A correlation-based network analysis evidenced the sociality and topological roles of the autophagy-related genes after serum starvation. Structural and functional tests identified a core set of autophagy related genes, suggesting different scenarios of autophagic responses to starvation, which may be responsible for the clinical variations associated with pancreatic cancer pathogenesis.

引用

页码：667 / 678

页数：12

共 43 条

[1] Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21 [J].

Aita, VM ;

Liang, XH ;

Murty, VVVS ;

Pincus, DL ;

Yu, WP ;

Cayanis, E ;

Kalachikov, S ;

Gilliam, TC ;

Levine, B .

GENOMICS, 1999, 59 (01) :59-65

[2] Improved scoring of functional groups from gene expression data by decorrelating GO graph structure [J].

Alexa, Adrian ;

Rahnenfuehrer, Joerg ;

Lengauer, Thomas .

BIOINFORMATICS, 2006, 22 (13) :1600-1607

[3] Autophagy-A double-edged sword in oncology [J].

Apel, Anja ;

Zentgraf, Hanswalter ;

Buechler, Markus W. ;

Herr, Ingrid .

INTERNATIONAL JOURNAL OF CANCER, 2009, 125 (05) :991-995

[4] An automated method for finding molecular complexes in large protein interaction networks [J].

Bader, GD ;

Hogue, CW .

BMC BIOINFORMATICS, 2003, 4 (1)

[5] Network science [J].

Barabasi, Albert-Laszlo .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 2013, 371 (1987)

[6] The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity [J].

Barretina, Jordi ;

Caponigro, Giordano ;

Stransky, Nicolas ;

Venkatesan, Kavitha ;

Margolin, Adam A. ;

Kim, Sungjoon ;

Wilson, Christopher J. ;

Lehar, Joseph ;

Kryukov, Gregory V. ;

Sonkin, Dmitriy ;

Reddy, Anupama ;

Liu, Manway ;

Murray, Lauren ;

Berger, Michael F. ;

Monahan, John E. ;

Morais, Paula ;

Meltzer, Jodi ;

Korejwa, Adam ;

Jane-Valbuena, Judit ;

Mapa, Felipa A. ;

Thibault, Joseph ;

Bric-Furlong, Eva ;

Raman, Pichai ;

Shipway, Aaron ;

Engels, Ingo H. ;

Cheng, Jill ;

Yu, Guoying K. ;

Yu, Jianjun ;

Aspesi, Peter, Jr. ;

de Silva, Melanie ;

Jagtap, Kalpana ;

Jones, Michael D. ;

Wang, Li ;

Hatton, Charles ;

Palescandolo, Emanuele ;

Gupta, Supriya ;

Mahan, Scott ;

Sougnez, Carrie ;

Onofrio, Robert C. ;

Liefeld, Ted ;

MacConaill, Laura ;

Winckler, Wendy ;

Reich, Michael ;

Li, Nanxin ;

Mesirov, Jill P. ;

Gabriel, Stacey B. ;

Getz, Gad ;

Ardlie, Kristin ;

Chan, Vivien ;

Myer, Vic E. .

NATURE, 2012, 483 (7391) :603-607

[7] Dismantling the autophagic arsenal when it is time to die Concerted AMBRA1 degradation by caspases and calpains [J].

Corazzari, Marco ;

Fimia, Gian Maria ;

Piacentini, Mauro .

AUTOPHAGY, 2012, 8 (08) :1255-1257

[8] The tumour suppressor p53 regulates the expression of amyloid precursor protein (APP) [J].

Cuesta, Ascension ;

Zambrano, Alberto ;

Royo, Maria ;

Pascual, Angel .

BIOCHEMICAL JOURNAL, 2009, 418 :643-650

[9] Phenotype and Genotype of Pancreatic Cancer Cell Lines [J].

Deer, Emily L. ;

Gonzalez-Hernandez, Jessica ;

Coursen, Jill D. ;

Shea, Jill E. ;

Ngatia, Josephat ;

Scaife, Courtney L. ;

Firpo, Matthew A. ;

Mulvihill, Sean J. .

PANCREAS, 2010, 39 (04) :425-435

[10] Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis [J].

Degenhardt, Kurt ;

Mathew, Robin ;

Beaudoin, Brian ;

Bray, Kevin ;

Anderson, Diana ;

Chen, Guanghua ;

Mukherjee, Chandreyee ;

Shi, Yufang ;

Gelinas, Celine ;

Fan, Yongjun ;

Nelson, Deirdre A. ;

Jin, Shengkan ;

White, Eileen .

CANCER CELL, 2006, 10 (01) :51-64

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