Antagonistic effect between tigecycline and meropenem: successful management of KPC-producing Klebsiella pneumoniae infection

被引：12

作者：

Bi, Sheng ^{[1
]}

Yao, Xin ^{[2
]}

Huang, Cheng ^{[1
,3
]}

Zheng, Xia ^{[4
]}

Xuan, Tianming ^{[5
]}

Sheng, Jifang ^{[1
]}

Xu, Kaijin ^{[1
]}

Zheng, Beiwen ^{[1
,7
]}

Yang, Qing ^{[6
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou, Zhejiang, Peoples R China

[3] Lihuili Hosp, Ningbo Med Ctr, Dept Resp Med, Ningbo, Peoples R China

[4] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Intens Care Unit, Hangzhou, Zhejiang, Peoples R China

[5] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Cardiovasc, Hangzhou, Zhejiang, Peoples R China

[6] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Ctr Clin Lab, Hangzhou, Zhejiang, Peoples R China

[7] Chinese Acad Inspect & Quarantine, Inst Anim Quarantine, Beijing, Peoples R China

来源：

INFECTION | 2019年 / 47卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Carbapenem-resistance; KPC-2-producing Klebsiella pneumoniae; Tigecycline; Meropenem; Antagonistic effect; GENTAMICIN; POLYMYXIN; EFFICACY; THERAPY;

D O I：

10.1007/s15010-019-01274-w

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

IntroductionA woman infected by carbapenem-resistant Klebsiella pneumoniae is reported in this study.Case reportTigecycline and meropenem combination was used, and indeed, in vitro checkerboard synergy test confirmed the antagonism between the two antibiotics. Thus, meropenem was ceased and single high-dose tigecycline was successful against the infection. Subsequent experiments showed that the isolates of the KPC-2-producing K. pneumoniae ST11 clone caused the infection.ConclusionTherefore, tigecycline and meropenem combination should be used with caution.

引用

页码：497 / 500

页数：4

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