In situ citric acid crosslinking of alginate/polyvinyl alcohol electrospun nanofibers

被引：88

作者：

Stone, Stephanie A. ^{[1
]}

Gosavi, Pallavi ^{[1
]}

Athauda, Thushara J. ^{[1
]}

Ozer, Ruya R. ^{[1
]}

机构：

[1] Univ Tulsa, Dept Chem & Biochem, Tulsa, OK 74104 USA

来源：

MATERIALS LETTERS | 2013年 / 112卷

关键词：

Alginate; Electrospinning; Crosslinking; Nanofibers; Biomaterials; ALGINATE; GLUTARALDEHYDE; HYDROGELS;

D O I：

10.1016/j.matlet.2013.08.100

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

This study reports in situ crosslinking of electrospun alginate/polyvinyl alcohol nanofibers using citric acid. Porous, interconnected network of nanofibers (mean diameter=250 +/- 30 nm) were electrospun from a homogeneous blend of sodium alginate-polyvinyl alcohol (1:1 weight ratio) containing 5 wt% citric acid. Electrospun nanofibers were then cured at 140 degrees C for 2 h and conditioned at room temperature before analysis. Crosslinked electrospun fibers were found thermally more stable and relatively insoluble in both water and simulated body fluid (SBF). Nanofibers remained intact after being immersed in deionized water or SBF for 2 days. On the other hand, the non-crosslinked electrospun nanofibers dissolved immediately. No significant change in the mechanical properties of the crosslinked alginate/PVA was observed after repetitive water immersion and drying cycles. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：32 / 35

页数：4

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