Risk factors for Alzheimer's disease: A case-control study

被引：25
作者：
Wang, PN
Wang, SJ
Hong, CJ
Liu, TT
Fuh, JL
Chi, CW
Liu, CY
Liu, HC
机构：
[1] VET GEN HOSP,NEUROL INST,TAIPEI,TAIWAN
[2] VET GEN HOSP,DEPT PSYCHIAT,TAIPEI,TAIWAN
[3] NATL YANG MING UNIV,SCH MED,TAIPEI,TAIWAN
[4] CHANG GUNG MED COLL,DEPT PSYCHIAT,TAIPEI,TAIWAN
来源：
NEUROEPIDEMIOLOGY | 1997年 / 16卷 / 05期
关键词：
Alzheimer's disease; risk factors; apolipoprotein E; smoking; well water;
D O I：
10.1159/000109692
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The extent of current knowledge of risk factors for Alzheimer's disease (AD) is still limited. We conducted a case-control study of 98 AD patients and 98 age-and sex-matched controls. Light smoking had a decreased risk for AD (AD: 2.0%, controls: 21.4%, odds ratio = 0.10, p = 0.003), whereas daily smoking showed a trend to increase the risk for AD (AD: 45.9%, controls: 26.5%, odds ratio = 1.73, p = 0.08). After multivariable analyses factors associated with AD included the presence of apolipoprotein epsilon 4 allele, and the duration of well water consumption.
引用
收藏
页码：234 / 240
页数：7
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