Neuronal circuits that regulate feeding behavior and metabolism

被引：201

作者：

Sohn, Jong-Woo ^{[1
]}

Elmquist, Joel K. ^{[1
,2
]}

Williams, Kevin W. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

来源：

TRENDS IN NEUROSCIENCES | 2013年 / 36卷 / 09期

基金：

美国国家卫生研究院;

关键词：

electrophysiology; melanocortin receptor; agonti-related peptide; neuropeptide Y receptor; GABA; glutamate; GREEN FLUORESCENT PROTEIN; HYPOTHALAMIC PROOPIOMELANOCORTIN NEURONS; NEUROPEPTIDE-Y NEURONS; BODY-WEIGHT; FOOD-INTAKE; ENERGY HOMEOSTASIS; LEPTIN ACTION; AGRP NEURONS; POMC NEURONS; MELANOCORTIN-4; RECEPTORS;

D O I：

10.1016/j.tins.2013.05.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurons within the central nervous system receive humoral and central (neurotransmitter or neuropeptide) signals that ultimately regulate ingestive behavior and metabolism. Recent advances in mouse genetics combined with neuroanatomical and electrophysiological techniques have contributed to a better understanding of these central mechanisms. This review integrates recently defined cellular mechanisms and neural circuits relevant to the regulation of feeding behavior, energy expenditure, and glucose homeostasis by metabolic signals.

引用

页码：504 / 512

页数：9

共 99 条

[1] Mechanisms of neuropeptide Y, peptide YY, and pancreatic polypeptide inhibition of identified green fluorescent protein-expressing GABA neurons in the hypothalamic neuroendocrine arcuate nucleus [J].

Acuna-Goycolea, C ;

Tamamaki, N ;

Yanagawa, Y ;

Obata, K ;

van den Pol, AN .

JOURNAL OF NEUROSCIENCE, 2005, 25 (32) :7406-7419

[2] Peptide YY3-36 inhibits both anorexigenic proopiomelanocortin and orexigenic neuropeptide Y neurons:: Implications for hypothalamic regulation of energy homeostasis [J].

Acuna-Goycolea, C ;

van den Pol, AN .

JOURNAL OF NEUROSCIENCE, 2005, 25 (45) :10510-10519

[3] Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons [J].

Al-Qassab, Hind ;

Smith, Mark A. ;

Irvine, Elaine E. ;

Guillermet-Guibert, Julie ;

Claret, Marc ;

Choudhury, Agharul I. ;

Selman, Colin ;

Piipari, Kaisa ;

Clements, Melanie ;

Lingard, Steven ;

Chandarana, Keval ;

Bell, Jimmy D. ;

Barsh, Gregory S. ;

Smith, Andrew J. H. ;

Batterham, Rachel L. ;

Ashford, Michael L. J. ;

Vanhaesebroeck, Bart ;

Withers, Dominic J. .

CELL METABOLISM, 2009, 10 (05) :343-354

[4] The Brain Activity Map Project and the Challenge of Functional Connectomics [J].

Alivisatos, A. Paul ;

Chun, Miyoung ;

Church, George M. ;

Greenspan, Ralph J. ;

Roukes, Michael L. ;

Yuste, Rafael .

NEURON, 2012, 74 (06) :970-974

[5] AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training [J].

Aponte, Yexica ;

Atasoy, Deniz ;

Sternson, Scott M. .

NATURE NEUROSCIENCE, 2011, 14 (03) :351-355

[6] Deconstruction of a neural circuit for hunger [J].

Atasoy, Deniz ;

Betley, J. Nicholas ;

Su, Helen H. ;

Sternson, Scott M. .

NATURE, 2012, 488 (7410) :172-+

[7] Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis [J].

Baldock, Paul A. ;

Allison, Susan J. ;

Lundberg, Pernilla ;

Lee, Nicola J. ;

Slack, Katy ;

Lin, En-Ju D. ;

Enriquez, Ronaldo F. ;

McDonald, Michelle M. ;

Zhang, Lei ;

During, Matthew J. ;

Little, David G. ;

Eisman, John A. ;

Gardiner, Edith M. ;

Yulyaningsih, Ernie ;

Lin, Shu ;

Sainsbury, Amanda ;

Herzog, Herbert .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (26) :19092-19102

[8] Divergence of melanocortin pathways in the control of food intake and energy expenditure [J].

Balthasar, N ;

Dalgaard, LT ;

Lee, CE ;

Yu, J ;

Funahashi, H ;

Williams, T ;

Ferreira, M ;

Tang, V ;

McGovern, RA ;

Kenny, CD ;

Christiansen, LM ;

Edelstein, E ;

Choi, B ;

Boss, O ;

Aschkenasi, C ;

Zhang, CY ;

Mountjoy, K ;

Kishi, T ;

Elmquist, JK ;

Lowell, BB .

CELL, 2005, 123 (03) :493-505

[9] Leptin receptor signaling in is required for normal body POW neurons weight homeostasis [J].

Balthasar, N ;

Coppari, R ;

McMinn, J ;

Liu, SM ;

Lee, CE ;

Tang, V ;

Kenny, CD ;

McGovern, RA ;

Chua, SC ;

Elmquist, JK ;

Lowell, BB .

NEURON, 2004, 42 (06) :983-991

[10] A New Oxytocin-Saporin Cytotoxin for Lesioning Oxytocin-Receptive Neurons in the Rat Hindbrain [J].

Baskin, Denis G. ;

Kim, Francis ;

Gelling, Richard W. ;

Russell, Brian J. ;

Schwartz, Michael W. ;

Morton, Gregory J. ;

Simhan, Hyagriv N. ;

Moralejo, Daniel H. ;

Blevins, James E. .

ENDOCRINOLOGY, 2010, 151 (09) :4207-4213

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