Diagnosis and management of inhalation injury: an updated review

被引：156

作者：

Walker, Patrick F. ^{[1
]}

Buehner, Michelle F. ^{[2
]}

Wood, Leslie A. ^{[3
]}

Boyer, Nathan L. ^{[3
]}

Driscoll, Ian R. ^{[4
]}

Lundy, Jonathan B. ^{[4
]}

Cancio, Leopoldo C. ^{[4
]}

Chung, Kevin K. ^{[4
,5
]}

机构：

[1] Walter Reed Natl Mil Med Ctr, Dept Surg, Bethesda, MD 20889 USA

[2] San Antonio Mil Med Ctr, Dept Gen Surg, Ft Sam Houston, TX 78234 USA

[3] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA

[4] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA

[5] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA

来源：

CRITICAL CARE | 2015年 / 19卷

关键词：

FREQUENCY PERCUSSIVE VENTILATION; ACUTE LUNG INJURY; PEROXYNITRITE DECOMPOSITION CATALYST; ACUTE SMOKE-INHALATION; BURN PATIENTS; MECHANICAL VENTILATION; FIBEROPTIC BRONCHOSCOPY; PULMONARY DYSFUNCTION; PEDIATRIC-PATIENTS; AIRWAY PRESSURE;

D O I：

10.1186/s13054-015-1077-4

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

In this article we review recent advances made in the pathophysiology, diagnosis, and treatment of inhalation injury. Historically, the diagnosis of inhalation injury has relied on nonspecific clinical exam findings and bronchoscopic evidence. The development of a grading system and the use of modalities such as chest computed tomography may allow for a more nuanced evaluation of inhalation injury and enhanced ability to prognosticate. Supportive respiratory care remains essential in managing inhalation injury. Adjuncts still lacking definitive evidence of efficacy include bronchodilators, mucolytic agents, inhaled anticoagulants, nonconventional ventilator modes, prone positioning, and extracorporeal membrane oxygenation. Recent research focusing on molecular mechanisms involved in inhalation injury has increased the number of potential therapies.

引用

页数：12

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