Atomic force microscopy: a tool to analyze the viral cycle

被引：1

作者：

Bernaud, Julien ^{[1
]}

Castelnovo, Martin ^{[1
]}

Muriaux, Delphine ^{[2
]}

Faivre-Moskalenko, Cendrine ^{[1
]}

机构：

[1] Ecole Normale Super Lyon, Phys Lab, CNRS, UMR 5672, F-69364 Lyon 07, France

[2] CNRS, UMR 5236, Ctr Etude Agents Pathogenes & Biotechnol Sante, F-34293 Montpellier 5, France

来源：

M S-MEDECINE SCIENCES | 2015年 / 31卷 / 05期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; MECHANICAL-PROPERTIES; HIV; CELLS; MANIPULATION; PARTICLES; LIFE;

D O I：

10.1051/medsci/20153105014

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Each step of the HIV-1 life cycle frequently involves a change in the morphology and/or mechanical properties of the viral particle or core. The atomic force microscope (AFM) constitutes a powerful tool for characterizing these physical changes at the scale of a single virus. Indeed, AFM enables the visualization of viral capsids in a controlled physiological environment and to probe their mechanical properties by nano-indentation. Finally, AFM force spectroscopy allows to characterize the affinities between viral envelope proteins and cell receptors at the single molecule level.

引用

页码：522 / 528

页数：7

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