African Swine Fever Virus

被引：0

作者：

Tulman, E. R. ^{[2
,3
]}

Delhon, G. A. ^{[1
]}

Ku, B. K. ^{[4
]}

Rock, D. L. ^{[1
]}

机构：

[1] Univ Illinois, Dept Pathobiol, Coll Vet Med, Urbana, IL 61802 USA

[2] Univ Connecticut, Dept Pathobiol & Vet Sci, Storrs, CT 06269 USA

[3] Univ Connecticut, Ctr Excellence Vaccine Res, Storrs, CT 06269 USA

[4] Natl Vet Res & Quarantine Serv, Anyang 430016, Kyonggi Do, South Korea

来源：

LESSER KNOWN LARGE DSDNA VIRUSES | 2009年 / 328卷

关键词：

DNA-POLYMERASE-X; HERPES-SIMPLEX-VIRUS; ORNITHODOROS-MOUBATA-PORCINUS; MAJOR CAPSID PROTEIN; MONKEY KIDNEY-CELLS; CELLULAR PHOSPHATASE CALCINEURIN; UBIQUITIN-CONJUGATING ENZYME; TRANSCRIPTION FACTOR-SII; CENTRAL VARIABLE REGION; IN-SITU HYBRIDIZATION;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

African swine fever virus (ASFV) is a large, intracytoplasmically-replicating DNA arbovirus and the sole member of the family Asfarviridae. It is the etiologic agent of a highly lethal hemorrhagic disease of domestic swine and therefore extensively studied to elucidate the structures, genes, and mechanisms affecting viral replication in the host, virus-host interactions, and viral virulence. Increasingly apparent is the complexity with which ASFV replicates and interacts with the host cell during infection. ASFV encodes novel genes involved in host immune response modulation, viral virulence for domestic swine, and in the ability of ASFV to replicate and spread in its tick vector. The unique nature of ASFV has contributed to a broader understanding of DNA virus/host interactions.

引用

页码：43 / 87

页数：45

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