Chiral Separation of R,S Clopidogrel with Monolithic Molecularly Imprinted Polymers

被引：0

作者：

Li, Zhiwei ^{[1
]}

Gao, Yanling ^{[1
]}

Xia, Jin ^{[1
]}

He, Qingguo ^{[2
]}

机构：

[1] Hebei Univ Sci & Technol, Coll Chem & Pharmaceut Enginering, Shijiazhuang, Peoples R China

[2] Shijiazhuang Zhitong Pharmaceut Technol Co Ltd, Shijiazhuang, Peoples R China

来源：

PROCEEDINGS OF THE 2015 ASIA-PACIFIC ENERGY EQUIPMENT ENGINEERING RESEARCH CONFERENCE (AP3ER 2015) | 2015年 / 9卷

关键词：

monolithic column; molecularly imprinted polymers; chiral separation;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A monolithic column of molecularly imprinted polymer was prepared by an in situ polymerization method with a compound clopidogrel as the template. The molecular recognition capabilities of the prepared monolithic MIP were evaluated by separating the enantiomers. The characteristics of the column and the influences of mobile phases were studied. The results showed that the monolithic column has chiral recognition capability for the template and the enantiomers were baseline separated even in aqueous solution.

引用

页码：314 / 317

页数：4

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