Cardiomyopathy in a Dish: Using Human Inducible Pluripotent Stem Cells to Model Inherited Cardiomyopathies

被引：13
作者：
Kamdar, Forum
Kamdar, Andre Klaassen
Koyano-Nakagawa, Naoko
Garry, Mary G.
Garry, Daniel J. [1 ]
机构：
[1] Univ Minnesota, Lillehei Heart Inst, Minneapolis, MN 55455 USA
来源：
JOURNAL OF CARDIAC FAILURE | 2015年 / 21卷 / 09期
基金：
美国国家卫生研究院;
关键词：
Cardiomyopathy; stem cells; disease models; LONG-QT SYNDROME; POLYMORPHIC VENTRICULAR-TACHYCARDIA; HYPERTROPHIC CARDIOMYOPATHY; DILATED CARDIOMYOPATHY; POMPE DISEASE; CARDIOMYOCYTES; DIFFERENTIATION; MECHANISMS; INDUCTION; MUTATION;
D O I：
10.1016/j.cardfail.2015.04.010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Inherited cardiomyopathies, including hypertrophic cardiomyopathy, dilated cardiomyopathies, arrythmogenic right ventricular cardiomyopathy, and other inherited forms of heart failure, represent a unique set of genetically defined cardiovascular disease processes. Unraveling the molecular mechanisms of these deadly forms of human heart disease has been challenging, but recent groundbreaking scientific advances in stem cell technology have allowed for the generation of patient-specific human inducible stem cell (hiPSC)-derived cardiomyocytes (CMs). hiPSC-derived CMs retain the genetic blueprint of the patient, they can be maintained in culture, and they recapitulate the phenotypic characteristics of the disease in vitro, thus serving as a disease in a dish. This review provides an overview of in vitro modeling of inherited cardiomyopathies with the use of patient-specific hiPSC-derived CMs.
引用
收藏
页码：761 / 770
页数：10
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