De novo biosynthetic pathways: rational design of microbial chemical factories

被引：108

作者：

Prather, Kristala L. Jones ^{[1
]}

Martin, Collin H. ^{[1
]}

机构：

[1] MIT, Dept Chem Engn, SynBERC, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2008年 / 19卷 / 05期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.copbio.2008.07.009

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Increasing interest in the production of organic compounds from non-petroleum-derived feedstocks, especially biomass, is a significant driver for the construction of new recombinant microorganisms for this purpose. As a discipline, Metabolic Engineering has provided a framework for the development of such systems. Efforts have traditionally been focused, first, on the optimization of natural producers, later progressing towards re-construction of natural pathways in heterologous hosts. To maximize the potential of microbes for biosynthetic purposes, new tools and methodologies within Metabolic Engineering are needed for the proposition and construction of de novo designed pathways. This review will focus on recent advances towards the design and assembly of biosynthetic pathways, and provide a Synthetic Biology perspective for the construction of microbial chemical factories.

引用

页码：468 / 474

页数：7

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