Copper(I)-Catalyzed Kinetic Resolution of N-Sulfonylaziridines with Indoles: Efficient Construction of Pyrroloindolines

被引：97

作者：

Chai, Zhuo ^{[1
]}

Zhu, You-Min ^{[1
]}

Yang, Pei-Jun ^{[1
]}

Wang, Shaoyin ^{[1
]}

Wang, Shaowu ^{[1
,2
]}

Liu, Zhen ^{[1
]}

Yang, Gaosheng ^{[1
]}

机构：

[1] Anhui Normal Univ, Coll Chem & Mat Sci, Anhui Lab Mol Based Mat,Inst Organ Chem, Key Lab Funct Mol Solids,Minist Educ, Wuhu 241000, Anhui, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 32期

基金：

中国国家自然科学基金;

关键词：

FORMAL 3+2 CYCLOADDITION; RING-OPENING REACTIONS; MESO-AZIRIDINES; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC CONSTRUCTION; VINYL AZIRIDINES; DESYMMETRIZATION; CYCLOPROPANES; NOCARDIOAZINES;

D O I：

10.1021/jacs.5b05820

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first Lewis acid catalyzed [3 + 2] annulation of indoles and 2-aryl-N-tosylaziridines was realized by using copper(I)/chiral diphosphine complexes as a catalyst. With this method, a variety of uniquely substituted chiral pyrroloindolines bearing multiple contiguous stereogenic centers were facilely accessed in a straightforward, high-yielding, and highly stereos elective way under mild conditions.

引用

页码：10088 / 10091

页数：4

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