Can We Treat Secondary Progressive Multiple Sclerosis Now?

被引：13

作者：

Bhatia, Rohit ^{[1
]}

Singh, Nishita ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Neurol, New Delhi, India

来源：

ANNALS OF INDIAN ACADEMY OF NEUROLOGY | 2019年 / 22卷 / 02期

关键词：

Disease modifying therapy; mitoxantrone; progressive MS; Secondary progressive MS; STEM-CELL TRANSPLANTATION; DOUBLE-BLIND; INTRAVENOUS IMMUNOGLOBULIN; MS; MITOXANTRONE; METHOTREXATE; RITUXIMAB; EFFICACY; THERAPY; BIOTIN;

D O I：

10.4103/aian.AIAN_345_18

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Secondary progressive multiple sclerosis (SPMS) is characterized by progressive accumulation of disability without intermittent recovery. Treatment of these patients is challenging due to limited understanding of pathogenesis and fewer therapeutic options. This article summarizes difficulties in defining and conducting trials in SPMS, review major clinical trials on therapies approved and unapproved in SPMS and lastly, therapies in pipeline for use in SPMS.

引用

页码：131 / 136

页数：6

共 46 条

[1]

Berkovich R., 2017, NEUROLOGY S, V88

[2] White and gray matter damage in primary progressive MS The chicken or the egg? [J].

Bodini, Benedetta ;

Chard, Declan ;

Altmann, Daniel R. ;

Tozer, Daniel ;

Miller, David H. ;

Thompson, Alan J. ;

Wheeler-Kingshott, Claudia ;

Ciccarelli, Olga .

NEUROLOGY, 2016, 86 (02) :170-176

[3] Double-Blind Controlled Randomized Trial of Cyclophosphamide versus Methylprednisolone in Secondary Progressive Multiple Sclerosis [J].

Brochet, Bruno ;

Deloire, Mathilde S. A. ;

Perez, Paul ;

Loock, Timothe ;

Baschet, Louise ;

Debouverie, Marc ;

Pittion, Sophie ;

Ouallet, Jean-Christophe ;

Clavelou, Pierre ;

de Seze, Jerome ;

Collongues, Nicolas ;

Vermersch, Patrick ;

Zephir, Helene ;

Castelnovo, Giovanni ;

Labauge, Pierre ;

Lebrun, Christine ;

Cohen, Mikael ;

Ruet, Aurelie .

PLOS ONE, 2017, 12 (01)

[4] Malignancies after mitoxantrone for multiple sclerosis: A retrospective cohort study [J].

Buttmann, Mathias ;

Seuffert, Linda ;

Maeder, Uwe ;

Toyka, Klaus V. .

NEUROLOGY, 2016, 86 (23) :2203-2207

[5] Autologous hematopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: comparison with secondary progressive multiple sclerosis [J].

Casanova, Bonaventura ;

Jarque, Isidro ;

Gascon, Francisco ;

Carlos Hernandez-Boluda, Juan ;

Perez-Miralles, Francisco ;

de la Rubia, Javier ;

Alcala, Carmen ;

Sanz, Jaime ;

Mallada, Javier ;

Cervello, Angeles ;

Navarre, Arantxa ;

Carcelen-Gadea, Maria ;

Bosca, Isabel ;

Gil-Perotin, Sara ;

Solano, Carlos ;

Angel Sanz, Miguel ;

Coret, Francisco .

NEUROLOGICAL SCIENCES, 2017, 38 (07) :1213-1221

[6] Azathioprine for multiple sclerosis [J].

Casetta, I ;

Iuliano, G. ;

Filippini, G. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2007, (04)

[7] Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial [J].

Chataway, Jeremy ;

Schuerer, Nadine ;

Alsanousi, Ali ;

Chan, Dennis ;

MacManus, David ;

Hunter, Kelvin ;

Anderson, Val ;

Bangham, Charles R. M. ;

Clegg, Shona ;

Nielsen, Casper ;

Fox, Nick C. ;

Wilkie, David ;

Nicholas, Jennifer M. ;

Calder, Virginia L. ;

Greenwood, John ;

Frost, Chris ;

Nicholas, Richard .

LANCET, 2014, 383 (9936) :2213-2221

[8] Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study [J].

Connick, Peter ;

Kolappan, Madhan ;

Crawley, Charles ;

Webber, Daniel J. ;

Patani, Rickie ;

Michell, Andrew W. ;

Du, Ming-Qing ;

Luan, Shi-Lu ;

Altmann, Daniel R. ;

Thompson, Alan J. ;

Compston, Alastair ;

Scott, Michael A. ;

Miller, David H. ;

Chandran, Siddharthan .

LANCET NEUROLOGY, 2012, 11 (02) :150-156

[9] Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT [J].

Dubreuil, Patrice ;

Letard, Sebastien ;

Ciufolini, Marco ;

Gros, Laurent ;

Humbert, Martine ;

Casteran, Nathalie ;

Borge, Laurence ;

Hajem, Berengere ;

Lermet, Anne ;

Sippl, Wolfgang ;

Voisset, Edwige ;

Arock, Michel ;

Auclair, Christian ;

Leventhal, Phillip S. ;

Mansfield, Colin D. ;

Moussy, Alain ;

Hermine, Olivier .

PLOS ONE, 2009, 4 (09)

[10]

Gray O, 2010, COCHRANE DB SYST REV, V2004, DOI [10.1002/14651858.CD003208.pub2, DOI 10.1002/14651858.CD003208.PUB2]

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