Physical exosome:exosome interactions

被引：108

作者：

Beit-Yannai, Elie ^{[1
]}

Tabak, Saray ^{[1
]}

Stamer, W. Daniel ^{[2
]}

机构：

[1] Ben Gurion Univ Negev, Clin Biochem & Pharmacol Dept, Beer Sheva, Israel

[2] Duke Univ, Duke Eye Ctr, Durham, NC USA

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2018年 / 22卷 / 03期

基金：

以色列科学基金会;

关键词：

exosome; zeta potential; hypothesis; signalling; physical interaction; HUMAN TRABECULAR MESHWORK; EXOSOMAL PROTEINS; CELLS; BIOMARKERS; CANCER; RNA; ENDOCYTOSIS; CULTURE; PLASMA; URINE;

D O I：

10.1111/jcmm.13479

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Exosomes are extracellular nanovesicles that mediate a number of cellular processes, including intracellular signalling. There are many published examples of exosome-exosome dimers; however, their relevance has not been explored. Here, we propose that cells release exosomes to physically interact with incoming exosomes, forming dimers that we hypothesize attenuate incoming exosome-mediated signalling. We discuss experiments to test this hypothesis and potential relevance in health and disease.

引用

页码：2001 / 2006

页数：6

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