Metformin decreases serum 8-hydroxy-2′-deoxyguanosine levels in polycystic ovary syndrome

被引:23
|
作者
Sova, Henri [1 ,2 ]
Puistola, Ulla [2 ]
Morin-Papunen, Laure [2 ]
Karihtala, Peeter [1 ,2 ]
机构
[1] Oulu Univ Hosp, Dept Radiotherapy & Oncol, Oulu 90029, Finland
[2] Oulu Univ Hosp, Dept Obstet & Gynecol, Oulu 90029, Finland
关键词
8-OHdG; metformin; oxidative stress; polycystic ovary syndrome; reactive oxygen species; INCREASED OXIDATIVE STRESS; REACTIVE OXYGEN; INSULIN-RESISTANCE; DNA-DAMAGE; WOMEN; RISK; 8-HYDROXYDEOXYGUANOSINE; REPAIR; MECHANISMS; BIOMARKER;
D O I
10.1016/j.fertnstert.2012.10.013
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To learn whether metformin treatment affects oxidative stress as measured by serum concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG). Design: Double-blind, randomized, placebo-controlled trial. Setting: University outpatient clinic. Patient(s): The study cohort consisted of 50 obese women (body mass index [BMI] >= 27 kg/m(2)) and 60 nonobese patients (BMI <27 kg/m(2)), mean age was 27.7 +/- 4.0 SD years. Intervention(s): Randomization to receive metformin or placebo for 3 months. Main Outcome Measure(s): Serum levels of 8-OHdG before and after medical treatment. Result(s): The levels of 8-OHdG were equal at baseline in the placebo and metformin groups. Obese women had higher baseline serum concentrations of 8-OHdG. Levels of 8-OHdG were statistically significantly reduced with metformin treatment, especially in obese patients with polycystic ovary syndrome. This study was a secondary subanalysis of a previously conducted prospective multicenter, randomized, placebo-controlled study on the effects of metformin on miscarriage, pregnancy, and miscarriage rates. Conclusion(s): Metformin treatment, compared with placebo, statistically significantly decreased 8-OHdG levels in women with polycystic ovary syndrome. Clinical Trial Registration Number: NCT00994812. (Fertil Steril (R) 2013; 99:593-8. (C) 2013 by American Society for Reproductive Medicine.)
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页码:593 / 598
页数:6
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