What factors determine the survival of patients with an acute exacerbation of interstitial lung disease after lung cancer resection?

被引：9

作者：

Miyajima, Masahiro ^{[1
]}

Watanabe, Atsushi ^{[1
]}

Sato, Toshihiko ^{[2
]}

Teramukai, Satoshi ^{[3
]}

Ebina, Masahito ^{[4
]}

Kishi, Kazuma ^{[5
]}

Sugiyama, Yukihiko ^{[6
]}

Kondo, Haruhiko ^{[7
]}

Kobayashi, Satoru ^{[8
]}

Takahashi, Yutaka ^{[9
]}

Ito, Hiroyuki ^{[10
]}

Yamamoto, Ryoji ^{[11
]}

Sawada, Shigeki ^{[12
]}

Fujimori, Hideki ^{[13
]}

Okabe, Kazunori ^{[14
]}

Arikura, Jun ^{[15
]}

Shintani, Yasushi ^{[16
]}

Nakamura, Hiroshige ^{[17
]}

Toyooka, Shinichi ^{[18
]}

Hasumi, Tohru ^{[19
]}

Watanabe, Takehiro ^{[20
]}

Hata, Yoshinobu ^{[21
]}

Iwata, Hisashi ^{[22
]}

Aoki, Minoru ^{[23
]}

Funai, Kazuhito ^{[24
]}

Inoue, Shuhei ^{[25
]}

Kawashima, Osamu ^{[26
]}

Iida, Tomohiko ^{[27
]}

Date, Hiroshi ^{[2
]}

机构：

[1] Sapporo Med Univ, Dept Thorac Surg, Sch Med, Chuo Ku, South 1,West 16, Sapporo, Hokkaido 0608543, Japan

[2] Kyoto Univ, Dept Thorac Surg, Kyoto, Japan

[3] Kyoto Prefectural Univ Med, Dept Biostat, Grad Sch Med Sci, Kyoto, Japan

[4] Tohoku Pharmaceut Univ Hosp, Resp Ctr, Sendai, Miyagi, Japan

[5] Toranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, Japan

[6] Jichi Med Univ, Dept Pulm Med, Shimotsuke, Tochigi, Japan

[7] Kyorin Univ, Dept Thorac Surg, Sch Med, Tokyo, Japan

[8] Dokkyo Med Univ, Dept Gen Thorac Surg, Mibu, Tochigi, Japan

[9] Kobe City Med Ctr Gen Hosp, Dept Resp Surg, Kobe, Hyogo, Japan

[10] Kanagawa Canc Ctr, Dept Thorac Surg, Yokohama, Kanagawa, Japan

[11] Osaka City Gen Hosp, Dept Gen Thorac Surg, Osaka, Japan

[12] Natl Hosp Org Shikoku Canc Ctr, Dept Thorac Surg, Matsuyama, Ehime, Japan

[13] Ishikawa Prefectural Cent Hosp, Dept Gen Thorac Surg, Kanazawa, Ishikawa, Japan

[14] Natl Hosp Org Yamaguchi Ube Med Ctr, Div Thorac Surg, Ube, Yamaguchi, Japan

[15] Natl Hosp Org Hokkaido Canc Ctr, Dept Chest Surg, Sapporo, Hokkaido, Japan

[16] Osaka Univ, Dept Gen Thorac Surg, Osaka, Japan

[17] Tottori Univ Hosp, Div Gen Thorac Surg, Yonago, Tottori, Japan

[18] Okayama Univ, Dept Thorac Breast & Endocrinol Surg, Okayama, Japan

[19] Tohoku Univ Hosp, Dept Thorac Surg, Sendai, Miyagi, Japan

[20] Nishi Niigata Chuo Natl Hosp, Dept Chest Surg, Natl Hosp Org, Niigata, Japan

[21] Toho Univ, Dept Surg, Sch Med, Tokyo, Japan

[22] Gifu Univ, Grad Sch Med, Dept Gen & Cardiothorac Surg, Gifu, Japan

[23] Nishi Kobe Med Ctr, Dept Thorac Surg, Kobe, Hyogo, Japan

[24] Hamamatsu Univ Sch Med, Dept Surg 1, Hamamatsu, Shizuoka, Japan

[25] Natl Hosp Org Higashi Ohmi Gen Med Ctr, Dept Gen Thorac Surg, Higashi Ohmi, Japan

[26] Nishigunma Natl Hosp, Dept Thorac Surg, Natl Hosp Org, Gunma, Japan

[27] Kimitsu Cent Hosp, Dept Gen Thorac Surg, Chiba, Japan

来源：

SURGERY TODAY | 2018年 / 48卷 / 04期

关键词：

Primary lung cancer; Idiopathic interstitial pneumonia; Acute exacerbation of interstitial pneumonia; Sialylated carbohydrate antigen KL-6; Neoadjuvant chemotherapy; IDIOPATHIC PULMONARY-FIBROSIS; SURGICAL RESECTION; SCORING SYSTEM; SHORT-TERM; PIRFENIDONE; PNEUMONIA; RISK; VENTILATION; PREDICTORS; EMPHYSEMA;

D O I：

10.1007/s00595-017-1605-8

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Acute exacerbation of interstitial pneumonia (AEIP) is a leading cause of death after lung cancer resection in patients with interstitial lung disease. We retrospectively analyzed 1763 patients with non-small cell lung cancer with a clinical diagnosis of interstitial lung disease (ILD) who underwent lung cancer resection between 2000 and 2009 at 61 hospitals in Japan. AEIP occurred in 164 of 1763 (9.3%) patients with a mortality rate of 43.9% (72/164). Univariate and multivariate analyses were carried out to identify possible risk factors of fatal AEIP. We then analyzed the 164 patients who developed postoperative AEIP and identified the preoperative and postoperative risk factors. A multivariate regression analysis identified that the sex, percent vital capacity, neoadjuvant radiation, preoperative history of AEIP, preoperative use of steroids, usual interstitial pneumonia pattern on CT, and surgical procedures were independent preoperative risk factors for death due to AEIP. ILD patients with emphysema somehow showed a lower risk of fatal AEIP than those without emphysema in this study. This study revealed eight risk factors for fatal AEIP.

引用

页码：404 / 415

页数：12

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