Cyclization of a chiral oxazolidine as a key-step for the synthesis of functionalized piperidines

被引：58
作者：
Agami, C
Couty, F
Mathieu, H
机构：
[1] Lab. Synt. Asymetrique associe CNRS, Univ. Pierre et Marie Curie, 75005 Paris
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 23期
关键词：
D O I：
10.1016/0040-4039(96)00767-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Bicyclic oxazolidine 6, a potential precursor for the synthesis of enantiopure piperidines and indolizidines, was synthesized from (R)-phenylglycinol. A stereoselective addition of cyanide anion on this compound afforded ultimately (2S,3S)-3-hydroxypipecolic acid 9. (C) 1996 Published by Elsevier Science Ltd
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页码：4001 / 4002
页数：2
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