Cyclization of a chiral oxazolidine as a key-step for the synthesis of functionalized piperidines

被引：58

作者：

Agami, C

Couty, F

Mathieu, H

机构：

[1] Lab. Synt. Asymetrique associe CNRS, Univ. Pierre et Marie Curie, 75005 Paris

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 23期

关键词：

D O I：

10.1016/0040-4039(96)00767-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bicyclic oxazolidine 6, a potential precursor for the synthesis of enantiopure piperidines and indolizidines, was synthesized from (R)-phenylglycinol. A stereoselective addition of cyanide anion on this compound afforded ultimately (2S,3S)-3-hydroxypipecolic acid 9. (C) 1996 Published by Elsevier Science Ltd

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页码：4001 / 4002

页数：2

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