Raman microscopy as a novel tool to detect endothelial dysfunction

被引：20

作者：

Baranska, Malgorzata ^{[1
,2
]}

Kaczor, Agnieszka ^{[1
,2
]}

Malek, Kamilla ^{[1
,2
]}

Jaworska, Aleksandra ^{[1
,2
]}

Majzner, Katarzyna ^{[1
,2
]}

Staniszewska-Slezak, Emilia ^{[1
,2
]}

Pacia, Marta Z. ^{[1
,2
]}

Zajac, Grzegorz ^{[1
,2
]}

Dybas, Jakub ^{[1
,2
]}

Wiercigroch, Ewelina ^{[2
]}

机构：

[1] Jagiellonian Univ, Fac Chem, PL-30060 Krakow, Poland

[2] Jagiellonian Univ, JCET, Krakow, Poland

来源：

PHARMACOLOGICAL REPORTS | 2015年 / 67卷 / 04期

关键词：

Raman imaging; SERS; Diabetes; Systemic hypertension; Single cell analysis; INTRACELLULAR PH; OPTICAL-ACTIVITY; LIVE CELLS; BIOMOLECULAR STRUCTURE; GOLD NANOPARTICLES; MEVALONATE PATHWAY; INCISIVE PROBE; VASCULAR WALL; LIPID BODIES; SERS;

D O I：

10.1016/j.pharep.2015.03.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Raman microscopy, a label-free method with high spatial resolution, shows growing potential in various fields of medical diagnostics. Several proof-of-concept studies related to the application of Raman microscopy to detect endothelial dysfunction are summarized in this work. Both ex vivo measurements of the tissues in the murine models of endothelial pathologies, as well as in vitro investigations of the cell cultures in the context of cellular transport, drug action and inflammation processes are discussed. The future directions in application of Raman spectroscopy-based methods in such studies are also described. (C) 2015 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.

引用

页码：736 / 743

页数：8

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