Rosmarinic acid mitigates signs of systemic oxidative stress in streptozotocin-induced diabetes in rats

被引：10

作者：

Sotnikova, Ruzena ^{[1
]}

Kaprinay, Barbara ^{[1
]}

Navarova, Jana ^{[1
]}

机构：

[1] Slovak Acad Sci, Inst Expt Pharmacol & Toxicol, Bratislava 84104, Slovakia

来源：

GENERAL PHYSIOLOGY AND BIOPHYSICS | 2015年 / 34卷 / 04期

关键词：

Rosmarinic acid; Experimental diabetes in rats; Oxidative stress; GLUCOSAMINIDASE; POLYPHENOLS; NEPHROPATHY;

D O I：

10.4149/gpb_2015025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the work was to study the effect of rosmarinic acid (RA) on markers of oxidative stress in rats with diabetes. Diabetes was induced by streptozotocin (STZ), RA was administered orally for ten weeks. Water consumption was measured daily. Ten weeks after the first RA administration, urine was collected over 15 hours. N-acetyl-beta-D-glucosaminidase (NAGA) activity, levels of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) were determined in the pancreas, kidney, and plasma. RA administration to diabetic rats ameliorated markers of oxidative stress, as well as water consumption and urination. We assume that RA may mitigate STZ-induced diabetic manifestations by protecting rat tissues against damaging effect of free radicals.

引用

页码：449 / 452

页数：4

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