Gallic Acid Attenuates Platelet Activation and Platelet-Leukocyte Aggregation: Involving Pathways of Akt and GSK3β

被引：41

作者：

Chang, Shih-Sheng ^{[2
,3
]}

Lee, Viola S. Y. ^{[2
]}

Tseng, Yu-Lun ^{[2
,4
]}

Chang, Kuan-Cheng ^{[3
]}

Chen, Kuen-Bao ^{[5
]}

Chen, Yuh-Lien ^{[1
]}

Li, Chi-Yuan ^{[2
,5
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Grad Inst Anat & Cell Biol, Taipei 10051, Taiwan

[2] China Med Univ, Grad Inst Clin Med Sci, Taichung 40402, Taiwan

[3] China Med Univ Hosp, Dept Med, Div Cardiol, Taichung 40407, Taiwan

[4] China Med Univ Hosp, Dept Psychiat, Taichung 40407, Taiwan

[5] China Med Univ Hosp, Dept Anesthesiol, Taichung 40407, Taiwan

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2012年 / 2012卷

关键词：

GLYCOGEN-SYNTHASE KINASE-3; P-SELECTIN; PROTEIN-KINASE; HYDROGEN-PEROXIDE; GREEN TEA; ANTIOXIDANT; INVOLVEMENT; CONSUMPTION; MECHANISMS; GENERATION;

D O I：

10.1155/2012/683872

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Platelet activation and its interaction with leukocytes play an important role in atherothrombosis. Cardiovascular diseases resulted from atherothrombosis remain the major causes of death worldwide. Gallic acid, a major constituent of red wine and tea, has been believed to have properties of cardiovascular protection, which is likely to be related to its antioxidant effects. Nonetheless, there were few and inconsistent data regarding the effects of gallic acid on platelet function. Therefore, we designed this in vitro study to determine whether gallic acid could inhibit platelet activation and the possible mechanisms. From our results, gallic acid could concentration-dependently inhibit platelet aggregation, P-selectin expression, and platelet-leukocyte aggregation. Gallic acid prevented the elevation of intracellular calcium and attenuated phosphorylation of PKC alpha/p38 MAPK and Akt/GSK3 beta on platelets stimulated by the stimulants ADP or U46619. This is the first mechanistic explanation for the inhibitory effects on platelets from gallic acid.

引用

页数：8

共 45 条

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