Chronic rhinosinusitis: From one disease to different phenotypes

被引：37

作者：

Bachert, Claus ^{[1
]}

Zhang, Nan ^{[2
]}

van Zele, Thibaut ^{[1
]}

Gevaert, Philippe ^{[1
]}

机构：

[1] Ghent Univ Hosp, Upper Airway Res Lab URL, Dept Otorhinolaryngol, B-9000 Ghent, Belgium

[2] Zhongshan City Peoples Hosp, Dept Otorhinolaryngol, Zhongshan, Guangdong, Peoples R China

来源：

PEDIATRIC ALLERGY AND IMMUNOLOGY | 2012年 / 23卷

关键词：

Chronic rhinosinusitis; nasal polyps; TGF-ss; IL-5; IgE; NASAL POLYPS; IGE; ASSOCIATION; RHINITIS; ALLERGEN; ASTHMA;

D O I：

10.1111/j.1399-3038.2012.01318.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

To cite this article: Bachert C, Zhang N, van Zele T, Gevaert P. Chronic rhinosinusitis: From one disease to different phenotypes. Pediatr Allergy Immunol 2012: 23 (Suppl. 22): 24. Abstract Chronic rhinosinusitis (CRS) has now been discovered as a frequent disease affecting about 11% of the European population. In clinical terms, CRS may be differentiated in two phenotypes, CRS with and without nasal polyps. This differentiation is also confirmed by immunohistochemical studies on the remodeling pattern of those diseases, identifying TGF-beta as the key regulator. Further differentiation may be based on the inflammatory patterns, differentiating endotypes based on prominent T helper cell cytokines such as interleukin-5 and the presence of IgE antibodies against Staphylococcus aureus enterotoxins. The importance of those endotypes has been confirmed by innovative studies using humanized antibodies applied to nasal polyp disease, and by their predictive value for asthma comorbidity. Biomarkers may thus be needed to fully appreciate the CRS disease spectrum and its link to asthma.

引用

页码：2 / 4

页数：3

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