Controlling alternans in cardiac cells

被引：9

作者：

Li, M ^{[1
]}

Gilmour, RF ^{[1
]}

Riccio, ML ^{[1
]}

Otani, NF ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA

来源：

COMPUTERS IN CARDIOLOGY 2003, VOL 30 | 2003年 / 30卷

关键词：

D O I：

10.1109/CIC.2003.1291077

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We demonstrate that alternans, potentially dangerous alternations in action potential morphology, can be controlled in individual cardiac cells using stimuli that modify the underlying ion channel dynamics. The best time to apply the control current is during the early plateau phase of the action potential. Elimination of alternans has important clinical implications, since alternans is linked to dangerous cardiac rhythm disorders.

引用

页码：9 / 12

页数：4

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