Controlling alternans in cardiac cells

被引：9

作者：

Li, M ^{[1
]}

Gilmour, RF ^{[1
]}

Riccio, ML ^{[1
]}

Otani, NF ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA

来源：

COMPUTERS IN CARDIOLOGY 2003, VOL 30 | 2003年 / 30卷

关键词：

D O I：

10.1109/CIC.2003.1291077

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We demonstrate that alternans, potentially dangerous alternations in action potential morphology, can be controlled in individual cardiac cells using stimuli that modify the underlying ion channel dynamics. The best time to apply the control current is during the early plateau phase of the action potential. Elimination of alternans has important clinical implications, since alternans is linked to dangerous cardiac rhythm disorders.

引用

页码：9 / 12

页数：4

共 11 条

[1] Complex spiral wave dynamics in a spatially distributed ionic model of cardiac electrical activity
Courtemanche, M
[J]. CHAOS, 1996, 6 (04) : 579 - 600
[2] Ionic mechanism of electrical alternans
Fox, JJ
McHarg, JL
Gilmour, RF
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2002, 282 (02): : H516 - H530
[3] CONTROLLING CARDIAC CHAOS
GARFINKEL, A
SPANO, ML
DITTO, WL
WEISS, JN
[J]. SCIENCE, 1992, 257 (5074) : 1230 - 1235
[4] HALL MG, 2002, PHYS REV LETT, V257
[5] SPIRAL BREAKUP IN MODEL-EQUATIONS OF ACTION-POTENTIAL PROPAGATION IN CARDIAC TISSUE
KARMA, A
[J]. PHYSICAL REVIEW LETTERS, 1993, 71 (07) : 1103 - 1106
[6] LI M, IN PRESS ABME
[7] Mechanism linking T-wave alternans to the genesis of cardiac fibrillation
Pastore, JM
Girouard, SD
Laurita, KR
Akar, FG
Rosenbaum, DS
[J]. CIRCULATION, 1999, 99 (10) : 1385 - 1394
[8] Cardiac electrical restitution properties and stability of reentrant spiral waves: a simulation study
Qu, ZL
Weiss, JN
Garfinkel, A
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1999, 276 (01): : H269 - H283
[9] Strategy for control of complex low-dimensional dynamics in cardiac tissue
Watanabe, M
Gilmour, RF
[J]. JOURNAL OF MATHEMATICAL BIOLOGY, 1996, 35 (01) : 73 - 87
[10] Chaos and the transition to ventricular fibrillation - A new approach to antiarrhythmic drug evaluation
Weiss, JN
Garfinkel, A
Karagueuzian, HS
Qu, ZL
Chen, PS
[J]. CIRCULATION, 1999, 99 (21) : 2819 - 2826

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