Effect of mesopores on solidification of sirolimus self-microemulsifying drug delivery system

被引：6
作者：
Tao, Chun [1 ]
Yu, Yue [1 ,2 ]
Chen, Zhenzhen [1 ,2 ]
Zhang, Minxin [1 ]
Liu, Linlin [1 ]
Liu, Zhihong [1 ]
Zhang, Jialiang [1 ]
Zhang, Qian [2 ]
Song, Hongtao [1 ]
机构：
[1] Fujian Med Univ, Fuzhou Gen Hosp, Fuzong Clin Med Coll, Dept Pharm, Fuzhou 350025, Fujian, Peoples R China
[2] Fujian Med Univ, Coll Pharm, Fuzhou 350108, Fujian, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2018年 / 29卷 / 12期
关键词：
Mesopores; Mesoporous silica nanospheres; SBA-15; Self-microemulsifying drug delivery system; Sirolimus; Bioavailability; SILICA; BIOAVAILABILITY; DISSOLUTION; DESIGN; SEDDS;
D O I：
10.1016/j.cclet.2018.11.022
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
To investigate the influence of mesopores towards the solidification of self-microemulsifying drug delivery system (SMEDDS), mesoporous silica nanospheres (MSNs) and Santa Barbara Amorphous-15 (SBA-15) were compared. The MSNs had hydrodynamic size of 195.35 +/- 5.82 nm, and pore diameter of 2.70 nm. The SBA-15 had hydrodynamic size of 2312.19 +/- 106.93 nm, and pore diameter of 10.91 nm. The MSNs and SBA-15 showed similar loading efficiency of SMEDDS containing sirolimus (SRL). However, MSNs had higher drug dissolution and in vivo absorption, with relative bioavailability of 174.62%. Thus, the length of mesopores played a more important role in solidification of SMEDDS as compared with the pore diameter. This study suggests that the SMEDDS-MSNs can be a potential candidate for oral administration of hydrophobic drugs. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1849 / 1852
页数：4
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