Emerging role of KLF4 in human gastrointestinal cancer

被引：196

作者：

Wei, DY

Kanai, M

Huang, SY

Xie, KP

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA

[3] Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

来源：

CARCINOGENESIS | 2006年 / 27卷 / 01期

关键词：

D O I：

10.1093/carcin/bgi243

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent analyses revealed that Kruppel-like factors (KLFs) play important roles in both normal development and carcinogenesis. Of the 16 known KLFs, KLF4 has been shown to be involved in the regulation of proliferation, differentiation and tumorigenesis of gastrointestinal tract epithelium. Clinical, experimental and mechanistic findings indicate that KLF4 is a bona fide tumor suppressor for both gastric and colorectal cancers. In this review, we summarize how this growing area of research has formed and the challenging new frontiers for better understanding of the oncogenic potential of the KLFs.

引用

收藏

页码：23 / 31

页数：9

相关论文

共 50 条

[21] Prognostic significance of NANOG and KLF4 for breast cancer [J].

Takuya Nagata ;

Yutaka Shimada ;

Shinichi Sekine ;

Ryota Hori ;

Koshi Matsui ;

Tomoyuki Okumura ;

Shigeaki Sawada ;

Junya Fukuoka ;

Kazuhiro Tsukada .

Breast Cancer, 2014, 21 :96-101

[22] The role of PGC1-α and KLF4 in inhibiting the progression of human hepatoma cells [J].

Chi, Chin-Wen ;

Sung, Ming-Ta ;

Ho, Ann-Tin ;

Lee, Chin-Chun ;

Tu, Wei-Shan ;

Yin, Peng-Nein ;

Yin, Pen-Hui ;

Lee, Hsin-Chen ;

Lui, Wing-Yiu .

CANCER RESEARCH, 2011, 71

[23] The Role of PRMT7 and KLF4 in Driving the Malignant Progression of Gastric Cancer [J].

Dong, Peng ;

Liu, Meng ;

Feng, Yanfei ;

Bi, Xiaochen .

SCIENCE OF ADVANCED MATERIALS, 2023, 15 (06) :832-839

[24] Reprogramming the retina with Klf4 [J].

不详 .

DEVELOPMENT, 2019, 146 (16)

[25] Zebrafish klf4 plays a global role in primitive erythropoiesis [J].

Gardiner, M. R. ;

Gongora, M. ;

Gardiner, B. ;

Grimmond, S. ;

Perkins, A. C. .

BLOOD CELLS MOLECULES AND DISEASES, 2007, 38 (02) :169-169

[26] The role of KLF4 in phagocyte activation during infectious diseases [J].

Herta, Toni ;

Bhattacharyya, Aritra ;

Hippenstiel, Stefan ;

Zahlten, Janine .

FRONTIERS IN IMMUNOLOGY, 2025, 16

[27] Tissue-Specific miRNAs Regulate the Development of Thoracic Aortic Aneurysm: The Emerging Role of KLF4 Network [J].

Gasiule, Stase ;

Stankevicius, Vaidotas ;

Patamsyte, Vaiva ;

Razanskas, Raimundas ;

Zukovas, Giedrius ;

Kapustina, Zana ;

Zaliaduonyte, Diana ;

Benetis, Rimantas ;

Lesauskaite, Vaiva ;

Vilkaitis, Giedrius .

JOURNAL OF CLINICAL MEDICINE, 2019, 8 (10)

[28] MiRrored Regulation of KLF2 and KLF4 [J].

Hamik, Anne ;

Jain, Mukesh K. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012, 32 (04) :839-840

[29] The correlation of mucin phenotype and Klf4 expression in gastric cancer [J].

Stojnev, S. ;

Krstic, M. ;

Zivkovic, V. ;

Ilic, I. ;

Mihailovic, D. .

VIRCHOWS ARCHIV, 2015, 467 :S129-S129

[30] KLF4 Expression Correlates with the Degree of Differentiation in Colorectal Cancer [J].

Hu, Ruolei ;

Zuo, Yan ;

Zuo, Li ;

Liu, Chao ;

Zhang, Sumei ;

Wu, Qiang ;

Zhou, Qing ;

Gui, Shuyu ;

Wei, Wei ;

Wang, Yuan .

GUT AND LIVER, 2011, 5 (02) :154-159

← 1 2 3 4 5 →