Emerging role of KLF4 in human gastrointestinal cancer

被引：196
作者：
Wei, DY
Kanai, M
Huang, SY
Xie, KP
机构：
[1] Univ Texas, MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA
[2] Univ Texas, MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA
[3] Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA
来源：
CARCINOGENESIS | 2006年 / 27卷 / 01期
关键词：
D O I：
10.1093/carcin/bgi243
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent analyses revealed that Kruppel-like factors (KLFs) play important roles in both normal development and carcinogenesis. Of the 16 known KLFs, KLF4 has been shown to be involved in the regulation of proliferation, differentiation and tumorigenesis of gastrointestinal tract epithelium. Clinical, experimental and mechanistic findings indicate that KLF4 is a bona fide tumor suppressor for both gastric and colorectal cancers. In this review, we summarize how this growing area of research has formed and the challenging new frontiers for better understanding of the oncogenic potential of the KLFs.
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收藏
页码：23 / 31
页数：9
相关论文
共 109 条
[1]   Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor β control element required for expression of the smooth muscle cell differentiation marker SM22α in vivo [J].
Adam, PJ ;
Regan, CP ;
Hautmann, MB ;
Owens, GK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (48) :37798-37806
[2]   Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements [J].
Ai, WD ;
Liu, Y ;
Langlois, M ;
Wang, TC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (10) :8684-8693
[3]  
ANDERSON KP, 1995, MOL CELL BIOL, V15, P5957
[4]   Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer [J].
Baylin, SB ;
Esteller, M ;
Rountree, MR ;
Bachman, KE ;
Schuebel, K ;
Herman, JG .
HUMAN MOLECULAR GENETICS, 2001, 10 (07) :687-692
[5]   Developmental and cell type-specific expression of the zinc finger transcription factor Kruppel-like factor 4 (Klf4) in postnatal mouse testis [J].
Behr, R ;
Kaestner, KH .
MECHANISMS OF DEVELOPMENT, 2002, 115 (1-2) :167-169
[6]   Lung cancers detected by screening with spiral computed tomography have a malignant phenotype when analyzed by cDNA Mmicroarray [J].
Bianchi, F ;
Hu, JT ;
Pelosi, G ;
Cirincione, R ;
Ferguson, M ;
Ratcliffe, C ;
Di Fiore, PP ;
Gatter, K ;
Pezzella, F ;
Pastorino, U .
CLINICAL CANCER RESEARCH, 2004, 10 (18) :6023-6028
[7]   Kruppel-like factors: Three fingers in many pies [J].
Bieker, JJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (37) :34355-34358
[8]   Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer [J].
Black, AR ;
Black, JD ;
Azizkhan-Clifford, J .
JOURNAL OF CELLULAR PHYSIOLOGY, 2001, 188 (02) :143-160
[9]  
Brembeck FH, 2000, J BIOL CHEM, V275, P28230
[10]   The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice [J].
Brembeck, FH ;
Moffett, J ;
Wang, TC ;
Rustgi, AK .
GASTROENTEROLOGY, 2001, 120 (07) :1720-1728
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