Artemisinin-Based Antimalarial Drug Therapy: Molecular Pharmacology and Evolving Resistance

被引：33
|
作者：
Heller, Laura E.
Roepe, Paul D. [1 ]
机构：
[1] Georgetown Univ, Dept Chem, 37th & O St NW, Washington, DC 20057 USA
来源：
TROPICAL MEDICINE AND INFECTIOUS DISEASE | 2019年 / 4卷 / 02期
关键词：
heme adduct; PfPI3KIII; artemisinin target; UNCOMPLICATED FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; HEMOGLOBIN DEGRADATION; IN-VITRO; HEME; DERIVATIVES; ALKYLATION; MECHANISM; PARASITES; TRIOXANES;
D O I：
10.3390/tropicalmed4020089
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The molecular pharmacology of artemisinin (ART)-based antimalarial drugs is incompletely understood. Clinically, these drugs are used in combination with longer lasting partner drugs in several different artemisinin combination therapies (ACTs). ACTs are currently the standard of care against Plasmodium falciparum malaria across much of the world. A harbinger of emerging artemisinin resistance (ARTR), known as the delayed clearance phenotype (DCP), has been well documented in South East Asia (SEA) and is beginning to affect the efficacy of some ACTs. Though several genetic mutations have been associated with ARTR/DCP, a molecular mechanism remains elusive. This paper summarizes our current understanding of ART molecular pharmacology and hypotheses for ARTR/DCP.
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页数：18
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