Fractional Flow Reserve-Guided Coronary Revascularization: Evidence from Randomized and Non-Randomized Studies

被引：2

作者：

Paolucci, Luca ^{[1
]}

Mangiacapra, Fabio ^{[1
]}

Viscusi, Michele Mattia ^{[1
]}

Nusca, Annunziata ^{[1
]}

Zimbardo, Giuseppe ^{[2
]}

Cialdella, Pio ^{[2
]}

Donahue, Michael Edward ^{[2
]}

Calo, Leonardo ^{[2
]}

Ussia, Gian Paolo ^{[1
]}

Grigioni, Francesco ^{[1
]}

机构：

[1] Campus Biomed Univ, Unit Cardiovasc Sci, Dept Med, I-00128 Rome, Italy

[2] Policlin Casilino, Div Cardiol, I-00169 Rome, Italy

来源：

DIAGNOSTICS | 2022年 / 12卷 / 11期

关键词：

coronary artery disease; coronary revascularization; fractional flow reserve; ELEVATION MYOCARDIAL-INFARCTION; WAVE-FREE RATIO; ARTERY-DISEASE; MEDICAL THERAPY; FOLLOW-UP; NONCULPRIT LESIONS; STENOSIS SEVERITY; VS; ANGIOGRAPHY; NATURAL-HISTORY; INTERVENTION;

D O I：

10.3390/diagnostics12112659

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Simple visual estimation of coronary angiography is limited by several factors that can hinder the proper classification of coronary lesions. Fractional flow reserve (FFR) is the most widely used tool to perform a physiological evaluation of coronary stenoses. Compared to isolated angiography, FFR has been demonstrated to be more effective in selecting those lesions associated with myocardial ischemia and, accordingly, impaired outcomes. At the same time, deferring coronary intervention in those lesions that do not show ischemic FFR values has proven safe and not associated with adverse events. Despite a major randomized clinical trial (RCT) and several non-randomized studies showing that FFR-guided revascularization could be superior to isolated angiography in improving clinical outcomes, subsequent RCTs have reported conflicting results. In this review, we summarize the principles behind FFR and the data currently available in the literature, highlighting the main differences between randomized and non-randomized studies that investigated this topic.

引用

页数：11

共 72 条

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