Evidence for transgenerational metabolic programming in Drosophila

被引:81
作者
Buescher, Jessica L. [1 ]
Musselman, Laura P. [2 ]
Wilson, Christina A. [1 ]
Lang, Tieming [1 ]
Keleher, Madeline [1 ]
Baranski, Thomas J. [2 ]
Duncan, Jennifer G. [1 ]
机构
[1] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA
基金
美国国家卫生研究院;
关键词
GESTATIONAL DIABETES-MELLITUS; DIET-INDUCED OBESITY; BODY-MASS INDEX; INSULIN-RESISTANCE; RISK-FACTORS; WEIGHT-GAIN; CHILDHOOD; MELANOGASTER; METHYLATION; DYSFUNCTION;
D O I
10.1242/dmm.011924
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Worldwide epidemiologic studies have repeatedly demonstrated an association between prenatal nutritional environment, birth weight and susceptibility to adult diseases including obesity, cardiovascular disease and type 2 diabetes. Despite advances in mammalian model systems, the molecular mechanisms underlying this phenomenon are unclear, but might involve programming mechanisms such as epigenetics. Here we describe a new system for evaluating metabolic programming mechanisms using a simple, genetically tractable Drosophila model. We examined the effect of maternal caloric excess on offspring and found that a high-sugar maternal diet alters body composition of larval offspring for at least two generations, augments an obese-like phenotype under suboptimal (high-calorie) feeding conditions in adult offspring, and modifies expression of metabolic genes. Our data indicate that nutritional programming mechanisms could be highly conserved and support the use of Drosophila as a model for evaluating the underlying genetic and epigenetic contributions to this phenomenon.
引用
收藏
页码:1123 / 1132
页数:10
相关论文
共 45 条
  • [1] The role of larval fat cells in adult Drosophila melanogaster
    Aguila, Jerell R.
    Suszko, Justin
    Gibbs, Allen G.
    Hoshizaki, Deborah K.
    [J]. JOURNAL OF EXPERIMENTAL BIOLOGY, 2007, 210 (06) : 956 - 963
  • [2] METHODS FOR QUANTITATIVE-ANALYSIS OF TRANSCRIPTION IN LARVAE AND PREPUPAE
    ANDRES, AJ
    THUMMEL, CS
    [J]. METHODS IN CELL BIOLOGY, VOL 44, 1994, 44 : 565 - 573
  • [3] Backhaus B. S. E., 1984, DROSOPH INF SERV, V60, P210
  • [4] Childhood body-mass index and the risk of coronary heart disease in adulthood
    Baker, Jennifer L.
    Olsen, Lina W.
    Sorensen, Thorkild I. A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (23) : 2329 - 2337
  • [5] Diabetic larvae and obese flies -: Emerging studies of metabolism in Drosophila
    Baker, Keith D.
    Thummel, Carl S.
    [J]. CELL METABOLISM, 2007, 6 (04) : 257 - 266
  • [6] High-Fat-Diet-Induced Obesity and Heart Dysfunction Are Regulated by the TOR Pathway in Drosophila
    Birse, Ryan T.
    Choi, Joan
    Reardon, Kathryn
    Rodriguez, Jessica
    Graham, Suzanne
    Diop, Soda
    Ocorr, Karen
    Bodmer, Rolf
    Oldham, Sean
    [J]. CELL METABOLISM, 2010, 12 (05) : 533 - 544
  • [7] Prevalence and Predictors of Overweight and Insulin Resistance in Offspring of Mothers With Gestational Diabetes Mellitus
    Boerschmann, Heike
    Pflueger, Maren
    Henneberger, Lydia
    Ziegler, Anette-G
    Hummel, Sandra
    [J]. DIABETES CARE, 2010, 33 (08) : 1845 - 1849
  • [8] Nuclear Receptor DHR96 Acts as a Sentinel for Low Cholesterol Concentrations in Drosophila melanogaster
    Bujold, Mattea
    Gopalakrishnan, Akila
    Nally, Emma
    King-Jones, Kirst
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (03) : 793 - 805
  • [9] Weight status in childhood as a predictor of becoming overweight or hypertensive in early adulthood
    Field, AE
    Cook, NR
    Gillman, MW
    [J]. OBESITY RESEARCH, 2005, 13 (01): : 163 - 169
  • [10] Association of Maternal Weight Gain in Pregnancy With Offspring Obesity and Metabolic and Vascular Traits in Childhood
    Fraser, Abigail
    Tilling, Kate
    Macdonald-Wallis, Corrie
    Sattar, Naveed
    Brion, Marie-Jo
    Benfield, Li
    Ness, Andy
    Deanfield, John
    Hingorani, Aroon
    Nelson, Scott M.
    Smith, George Davey
    Lawlor, Debbie A.
    [J]. CIRCULATION, 2010, 121 (23) : 2557 - U48