Replicability and Heterogeneity of Awake Unrestrained Canine fMRI Responses

被引：50
作者：
Berns, Gregory S. [1 ]
Brooks, Andrew [1 ]
Spivak, Mark [2 ]
机构：
[1] Emory Univ, Ctr Neuropolicy, Atlanta, GA 30322 USA
[2] Comprehens Pet Therapy, Sandy Springs, GA USA
来源：
PLOS ONE | 2013年 / 8卷 / 12期
关键词：
FUNCTIONAL MRI; MONKEYS;
D O I：
10.1371/journal.pone.0081698
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Previously, we demonstrated the possibility of fMRI in two awake and unrestrained dogs. Here, we determined the replicability and heterogeneity of these results in an additional 11 dogs for a total of 13 subjects. Based on an anatomically placed region-of-interest, we compared the caudate response to a hand signal indicating the imminent availability of a food reward to a hand signal indicating no reward. 8 of 13 dogs had a positive differential caudate response to the signal indicating reward. The mean differential caudate response was 0.09%, which was similar to a comparable human study. These results show that canine fMRI is reliable and can be done with minimal stress to the dogs.
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页数：8
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