Replicability and Heterogeneity of Awake Unrestrained Canine fMRI Responses

被引：51

作者：

Berns, Gregory S. ^{[1
]}

Brooks, Andrew ^{[1
]}

Spivak, Mark ^{[2
]}

机构：

[1] Emory Univ, Ctr Neuropolicy, Atlanta, GA 30322 USA

[2] Comprehens Pet Therapy, Sandy Springs, GA USA

来源：

PLOS ONE | 2013年 / 8卷 / 12期

关键词：

FUNCTIONAL MRI; MONKEYS;

D O I：

10.1371/journal.pone.0081698

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Previously, we demonstrated the possibility of fMRI in two awake and unrestrained dogs. Here, we determined the replicability and heterogeneity of these results in an additional 11 dogs for a total of 13 subjects. Based on an anatomically placed region-of-interest, we compared the caudate response to a hand signal indicating the imminent availability of a food reward to a hand signal indicating no reward. 8 of 13 dogs had a positive differential caudate response to the signal indicating reward. The mean differential caudate response was 0.09%, which was similar to a comparable human study. These results show that canine fMRI is reliable and can be done with minimal stress to the dogs.

引用

页数：8

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