Polyprenylated Xanthones from Garcinia lancilimba Showing Apoptotic Effects against HeLa-C3 Cells

被引：35
作者：
Han, Quan-Bing [2 ]
Tian, Hong-Lei [1 ]
Yang, Nian-Yun [2 ]
Qiao, Chun-Feng [2 ]
Song, Jing-Zheng [2 ]
Chang, Donald C. [3 ]
Luo, Kathy Q. [1 ]
Xu, Hong-Xi [2 ]
机构：
[1] Hong Kong Univ Sci & Technol, Dept Chem Engn, Bioengn Grad Program, Kowloon, Hong Kong, Peoples R China
[2] Hong Kong Jockey Club Inst Chinese Med, Chinese Med Lab, Shatin, Hong Kong, Peoples R China
[3] Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Hong Kong, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2008年 / 5卷 / 12期
关键词：
D O I：
10.1002/cbdv.200890225
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three new prenylated xanthones, 1-3, along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR spectra, as well as HR-MS experiments. Some of these compounds showed apoptotic effects or growth-inhibition effects against HeLa cells expressing a caspase sensor protein.
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收藏
页码：2710 / 2717
页数：8
相关论文
共 29 条
  • [11] Xanthones with antimalarial activity from Garcinia dulcis
    Likhitwitayawuid, K
    Chanmahasathien, W
    Ruangrungsi, N
    Krungkrai, J
    [J]. PLANTA MEDICA, 1998, 64 (03) : 281 - 282
  • [12] Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in living HeLa cells
    Luo, KQ
    Yu, VC
    Pu, YM
    Chang, DC
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 283 (05) : 1054 - 1060
  • [13] Microtubules, microtubule-interfering agents and apoptosis
    Mollinedo, F
    Gajate, C
    [J]. APOPTOSIS, 2003, 8 (05) : 413 - 450
  • [14] Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway (Publication with Expression of Concern)
    Pandey, Manoj K.
    Sung, Bokyung
    Ahn, Kwang Seok
    Kunnumakkara, Ajaikumar B.
    Chaturvedi, Madan M.
    Aggarwal, Bharat B.
    [J]. BLOOD, 2007, 110 (10) : 3517 - 3525
  • [15] Tetraoxygenated naturally occurring xanthones
    Peres, V
    Nagem, TJ
    de Oliveira, FF
    [J]. PHYTOCHEMISTRY, 2000, 55 (07) : 683 - 710
  • [16] Benzopyran, biphenyl, and tetraoxygenated xanthone derivatives from the twigs of Garcinia nigrolineata
    Rukachaisirikul, V
    Tadpetch, K
    Watthanaphanit, A
    Saengsanae, N
    Phongpaichit, S
    [J]. JOURNAL OF NATURAL PRODUCTS, 2005, 68 (08): : 1218 - 1221
  • [17] Caged-tetraprenylated xanthones from Garcinia scortechinii
    Rukachaisirikul, V
    Kaewnok, W
    Koysomboon, S
    Phongpaichit, S
    Taylor, WC
    [J]. TETRAHEDRON, 2000, 56 (43) : 8539 - 8543
  • [18] Two new xanthones from the stems of Garcinia cowa
    Shen, J
    Yang, JS
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (01) : 126 - 128
  • [19] Taiwo O, 1999, PHYTOTHER RES, V13, P675, DOI 10.1002/(SICI)1099-1573(199912)13:8&lt
  • [20] 675::AID-PTR513&gt
123