Polyprenylated Xanthones from Garcinia lancilimba Showing Apoptotic Effects against HeLa-C3 Cells

被引：35
作者：
Han, Quan-Bing [2 ]
Tian, Hong-Lei [1 ]
Yang, Nian-Yun [2 ]
Qiao, Chun-Feng [2 ]
Song, Jing-Zheng [2 ]
Chang, Donald C. [3 ]
Luo, Kathy Q. [1 ]
Xu, Hong-Xi [2 ]
机构：
[1] Hong Kong Univ Sci & Technol, Dept Chem Engn, Bioengn Grad Program, Kowloon, Hong Kong, Peoples R China
[2] Hong Kong Jockey Club Inst Chinese Med, Chinese Med Lab, Shatin, Hong Kong, Peoples R China
[3] Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Hong Kong, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2008年 / 5卷 / 12期
关键词：
D O I：
10.1002/cbdv.200890225
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three new prenylated xanthones, 1-3, along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR spectra, as well as HR-MS experiments. Some of these compounds showed apoptotic effects or growth-inhibition effects against HeLa cells expressing a caspase sensor protein.
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收藏
页码：2710 / 2717
页数：8
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