Neural development: Bidirectional signals establish boundaries

被引:28
作者
Klein, R [1 ]
机构
[1] European Mol Biol Lab, D-69117 Heidelberg, Germany
关键词
D O I
10.1016/S0960-9822(99)80441-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent studies have shown that the formation of boundaries between the segments - rhombomeres of the vertebrate hindbrain depends on bidirectional signalling between neighbouring cells, This signalling is mediated by Eph receptors and their ligands, which has been found to restrict cell intermingling in vitro.
引用
收藏
页码:R691 / R694
页数:4
相关论文
共 14 条
  • [1] BERGEMANN AD, 1995, MOL CELL BIOL, V15, P4921
  • [2] The ephrins and Eph receptors in neural development
    Flanagan, JG
    Vanderhaeghen, P
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, 1998, 21 : 309 - 345
  • [3] Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis
    Gale, NW
    Holland, SJ
    Valenzuela, DM
    Flenniken, A
    Pan, L
    Ryan, TE
    Henkemeyer, M
    Strebhardt, K
    Hirai, H
    Wilkinson, DG
    Pawson, T
    Davis, S
    Yancopoulos, GD
    [J]. NEURON, 1996, 17 (01) : 9 - 19
  • [4] GUTHRIE S, 1991, DEVELOPMENT, V112, P221
  • [5] Nuk controls pathfinding of commissural axons in the mammalian central nervous system
    Henkemeyer, M
    Orioli, D
    Henderson, JT
    Saxton, TM
    Roder, J
    Pawson, T
    Klein, R
    [J]. CELL, 1996, 86 (01) : 35 - 46
  • [6] Holder N, 1999, DEVELOPMENT, V126, P2033
  • [7] Cell-contact-dependent signalling in axon growth and guidance:: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase β
    Holland, SJ
    Peles, E
    Pawson, T
    Schlessinger, J
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 1998, 8 (01) : 117 - 127
  • [8] Modulation of EphA receptor function by coexpressed EphrinA ligands on retinal ganglion cell axons
    Hornberger, MR
    Dütting, D
    Ciossek, T
    Yamada, T
    Handwerker, C
    Lang, S
    Weth, F
    Huf, J
    Wessel, R
    Logan, C
    Tanaka, H
    Drescher, U
    [J]. NEURON, 1999, 22 (04) : 731 - 742
  • [9] The gap junction communication channel
    Kumar, NM
    Gilula, NB
    [J]. CELL, 1996, 84 (03) : 381 - 388
  • [10] Patterning the vertebrate neuraxis
    Lumsden, A
    Krumlauf, R
    [J]. SCIENCE, 1996, 274 (5290) : 1109 - 1115