Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection

被引：28
|
作者：
Li, Min-hong [1 ,2 ]
Dong, Li-wei [1 ]
Li, Shuang-xi [1 ,2 ]
Tang, Gu-sheng [3 ]
Pan, Yu-fei [1 ]
Zhang, Jian [1 ]
Wang, Hui [2 ]
Zhou, Hua-bang [2 ]
Tan, Ye-xiong [1 ]
Hu, He-ping [2 ]
Wang, Hong-yang [1 ,2 ,4 ]
机构：
[1] Second Mil Med Univ, Int Cooperat Lab Signal Transduct, Eastern Hepatobiliary Surg Inst, Shanghai, Peoples R China
[2] Second Mil Med Univ, Dept Liver Med, Eastern Hepatobiliary Surg Hosp, Shanghai, Peoples R China
[3] Second Mil Med Univ, Dept Haematol, Changhai Hosp, Shanghai, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Med, State Key Lab Oncogenes & Related Genes, Shanghai Canc Inst,Renji Hosp, Shanghai, Peoples R China
来源：
CANCER LETTERS | 2013年 / 337卷 / 02期
基金：
中国国家自然科学基金;
关键词：
CKAP4; Intrahepatic cholangiocellular carcinomas; Prognosis; Overall survival; Disease-free survival; ANTIPROLIFERATIVE FACTOR; IMPROVED SURVIVAL; MEMBRANE-PROTEIN; BINDING-PROTEIN; II PNEUMOCYTES; ER; OVEREXPRESSION; IDENTIFICATION; CKAP4/P63; CARCINOMA;
D O I：
10.1016/j.canlet.2013.05.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The objective of the study was to investigate the clinical significance of CKAP4 in intrahepatic cholangio-cellular carcinoma (ICC). CKAP4 expression was determined in a cohort containing 173 cases of ICC patients. We found that CKAP4 was overexpressed in the majority of ICC cases and was significantly associated with tumor size, distant metastasis, lymph node metastasis, UICC and TNM stage features. Kaplan-Meier and Cox regression data indicated that CKAP4 was correlated with favorable clinical outcome and was an independent predictor for overall survival (HR, 0.646; 95% CI, 0.463-0.900 [p = 0.010]). Thus, CKAP4 may serve as a prognostic marker of ICC patients. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：248 / 253
页数：6
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