Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection

被引：28
作者：
Li, Min-hong [1 ,2 ]
Dong, Li-wei [1 ]
Li, Shuang-xi [1 ,2 ]
Tang, Gu-sheng [3 ]
Pan, Yu-fei [1 ]
Zhang, Jian [1 ]
Wang, Hui [2 ]
Zhou, Hua-bang [2 ]
Tan, Ye-xiong [1 ]
Hu, He-ping [2 ]
Wang, Hong-yang [1 ,2 ,4 ]
机构：
[1] Second Mil Med Univ, Int Cooperat Lab Signal Transduct, Eastern Hepatobiliary Surg Inst, Shanghai, Peoples R China
[2] Second Mil Med Univ, Dept Liver Med, Eastern Hepatobiliary Surg Hosp, Shanghai, Peoples R China
[3] Second Mil Med Univ, Dept Haematol, Changhai Hosp, Shanghai, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Med, State Key Lab Oncogenes & Related Genes, Shanghai Canc Inst,Renji Hosp, Shanghai, Peoples R China
来源：
CANCER LETTERS | 2013年 / 337卷 / 02期
基金：
中国国家自然科学基金;
关键词：
CKAP4; Intrahepatic cholangiocellular carcinomas; Prognosis; Overall survival; Disease-free survival; ANTIPROLIFERATIVE FACTOR; IMPROVED SURVIVAL; MEMBRANE-PROTEIN; BINDING-PROTEIN; II PNEUMOCYTES; ER; OVEREXPRESSION; IDENTIFICATION; CKAP4/P63; CARCINOMA;
D O I：
10.1016/j.canlet.2013.05.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The objective of the study was to investigate the clinical significance of CKAP4 in intrahepatic cholangio-cellular carcinoma (ICC). CKAP4 expression was determined in a cohort containing 173 cases of ICC patients. We found that CKAP4 was overexpressed in the majority of ICC cases and was significantly associated with tumor size, distant metastasis, lymph node metastasis, UICC and TNM stage features. Kaplan-Meier and Cox regression data indicated that CKAP4 was correlated with favorable clinical outcome and was an independent predictor for overall survival (HR, 0.646; 95% CI, 0.463-0.900 [p = 0.010]). Thus, CKAP4 may serve as a prognostic marker of ICC patients. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：248 / 253
页数：6
相关论文
共 25 条
[1]   Role of P63 (CKAP4) in binding of surfactant protein-A to type II pneumocytes [J].
Bates, Sandra R. ;
Kazi, Altaf S. ;
Tao, Jian-Qin ;
Yu, Kevin J. ;
Gonder, Daniel S. ;
Feinstein, Sheldon I. ;
Fisher, Aron B. .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2008, 295 (04) :L658-L669
[2]   Prognostic molecular markers in cholangiocarcinoma: A systematic review [J].
Briggs, Christopher D. ;
Neal, Christopher P. ;
Mann, Christopher D. ;
Steward, William P. ;
Manson, Margaret M. ;
Berry, David P. .
EUROPEAN JOURNAL OF CANCER, 2009, 45 (01) :33-47
[3]   CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients [J].
Conrads, Thomas P. ;
Tocci, Gillian M. ;
Hood, Brian L. ;
Zhang, Chen-Ou ;
Guo, Li ;
Koch, Kristopher R. ;
Michejda, Christopher J. ;
Veenstra, Timothy D. ;
Keay, Susan K. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (49) :37836-37843
[4]   Intrahepatic cholangiocardnoma - Rising frequency, improved survival, and determinants of outcome after resection [J].
Endo, Itaru ;
Gonen, Mithat ;
Yopp, Adam C. ;
Dalal, Kimberly M. ;
Zhou, Qin ;
Klimstra, David ;
DAngelica, Michael ;
DeMatteo, Ronald P. ;
Fong, Yuman ;
Schwartz, Lawrence ;
Kemeny, Nancy ;
O'Reilly, Eileen ;
Abou-Alfa, Ghassan K. ;
Shimada, Hiroshi ;
Blumgart, Leslie H. ;
Jarnagin, William R. .
ANNALS OF SURGERY, 2008, 248 (01) :84-96
[5]   Identification and characterization of p63 (CKAP4/ERGIC-63/CLIMP-63), a surfactant protein A binding protein, on type II pneumocytes [J].
Gupta, Nisha ;
Manevich, Yefim ;
Kazi, Altaf S. ;
Tao, Jian-Qin ;
Fisher, Aron B. ;
Bates, Sandra R. .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2006, 291 (03) :L436-L446
[6]   Reduced expression of syndecan-1 correlates with histologic dedifferentiation, lymph node metastasis, and poor prognosis in intrahepatic cholangiocarcinoma [J].
Harada, K ;
Masuda, S ;
Hirano, M ;
Nakanuma, Y .
HUMAN PATHOLOGY, 2003, 34 (09) :857-863
[7]   Overexpression of CD151 as an Adverse Marker for Intrahepatic Cholangiocarcinoma Patients [J].
Huang, Xiao-Yong ;
Ke, Ai-Wu ;
Shi, Guo-Ming ;
Ding, Zhen-Bin ;
Devbhandari, Ranjan Prasad ;
Gu, Fang-Ming ;
Li, Quan-Lin ;
Dai, Zhi ;
Zhou, Jian ;
Fan, Jia .
CANCER, 2010, 116 (23) :5440-5451
[8]   Fascin overexpression is involved in carcinogenesis and prognosis of human intrahepatic cholangiocarcinoma: immunohistochemical and molecular analysis [J].
Iguchi, Tomohiro ;
Aishima, Shinichi ;
Taketomi, Akinobu ;
Nishihara, Yunosuke ;
Fujita, Nobuhiro ;
Sanefuji, Kensaku ;
Sugimachi, Keishi ;
Yamashita, Yo-ichi ;
Maehara, Yoshihiko ;
Tsuneyoshi, Masazumi .
HUMAN PATHOLOGY, 2009, 40 (02) :174-180
[9]   Long-term survival and prognostic factors in the surgical treatment of mass-forming type cholangiocarcinoma [J].
Inoue, K ;
Makuuchi, M ;
Takayama, T ;
Torzilli, G ;
Yamamoto, J ;
Shimada, K ;
Kosuge, T ;
Yamasaki, S ;
Konishi, M ;
Kinoshita, T ;
Miyagawa, S ;
Kawasaki, S .
SURGERY, 2000, 127 (05) :498-505
[10]   CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity [J].
Karasawa, T. ;
Wang, Q. ;
David, L. L. ;
Steyger, P. S. .
CELL DEATH & DISEASE, 2010, 1 :e102-e102
123