Regioselective synthesis and antimicrobial evaluation of some thioether-amide linked 1,4-disubstituted 1,2,3-triazoles

被引：18
|
作者：
Kaushik, C. P. [1 ]
Pahwa, Ashima [1 ]
Thakur, Rajesh [2 ]
Kaur, Pawan [2 ]
机构：
[1] Guru Jambheshwar Univ Sci Technol, Dept Chem, Hisar 125001, Haryana, India
[2] Guru Jambheshwar Univ Sci Technol, Dept Bio & Nanotechnol, Hisar, Haryana, India
来源：
SYNTHETIC COMMUNICATIONS | 2017年 / 47卷 / 04期
关键词：
1,2,3-triazoles; 1,4-disubstitued; antibacterial activity; antifungal activity; click reaction; CLICK CHEMISTRY; BIOLOGICAL EVALUATION; INHIBITORS;
D O I：
10.1080/00397911.2016.1265983
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 1,4-disubstituted 1,2,3-triazoles having thioether as well as amide linkage were synthesized from aryl(prop-2-yn-1-yl)sulfanes and 2-azido-N-substituted acetamides through Cu(I) catalyzed click reaction. Structures of newly synthesized compounds (3a-3x) were confirmed by spectral techniques like FTIR, H-1 NMR, C-13 NMR, and HRMS. The synthesized triazoles were evaluated for in vitro antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Candida albicans, and Aspergillus niger. Compounds 3m and 3q displayed appreciable broad spectrum antimicrobial activity against tested microbial strains. The nanoformulations of compounds 3m and 3q were also prepared and examined against one bacterial strain and one fungal strain.
引用
收藏
页码：368 / 378
页数：11
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