Synthesis and structure-activity relationship of benzylamine supported platinum(IV) complexes

被引：35
作者：
Ameta, Rakesh Kumar [1 ]
Singh, Man [1 ]
Kale, Raosahab Kathalupant [1 ,2 ]
机构：
[1] Cent Univ Gujarat, Sch Chem Sci, Gandhinagar 382030, India
[2] Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India
来源：
NEW JOURNAL OF CHEMISTRY | 2013年 / 37卷 / 05期
关键词：
DNA-BINDING; BIOLOGICAL-ACTIVITY; PHOTOCLEAVAGE PROPERTIES; OXOVANADIUM COMPLEXES; PORPHYRINS; CYTOTOXICITY; REDUCTION; LIGANDS; CANCER; ACIDS;
D O I：
10.1039/c3nj41141a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of benzylamine derivative (BAD) supported platinum(IV) complexes (PtCl4(BADs)(2)) have been synthesized. The complexes were tested in vitro against the MCF-7 cell line, and the 4-fluoro and 4-chloro containing complexes expressed impressive anticancer activities. Their DNA binding nature for a structure-activity relationship (SAR) study was investigated with physicochemical-indicators (PCI) which categorized them as good intercalators for host-guest chemistry. A mechanism for drug efficacy is proposed by analysis of the resultant viscosity and surface tension of PtCl4(BADs)(2)-DNA solutions named as the drug-friccohesity interaction (DFI). The complexes have shown significant antioxidant activity, determined on the basis of free radical scavenging effects due to their terminating action against the reactive species.
引用
收藏
页码：1501 / 1508
页数：8
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