Functional and genetic deconstruction of the cellular origin in liver cancer

被引：255

作者：

Marquardt, Jens U. ^{[1
]}

Andersen, Jesper B. ^{[2
]}

Thorgeirsson, Snorri S. ^{[3
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Dept Med 1, D-55131 Mainz, Germany

[2] Univ Copenhagen, BRIC, DK-2200 Copenhagen N, Denmark

[3] NCI, Expt Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2015年 / 15卷 / 11期

基金：

英国医学研究理事会;

关键词：

GROWTH-FACTOR RECEPTOR; FACTOR-KAPPA-B; HEPATIC STELLATE CELLS; HEPATOCELLULAR-CARCINOMA; PROGENITOR-CELL; STEM-CELLS; INTRAHEPATIC CHOLANGIOCARCINOMAS; HEPATOCYTE DIFFERENTIATION; INACTIVATING MUTATIONS; ACTIVATING MUTATIONS;

D O I：

10.1038/nrc4017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

During the past decade, research on primary liver cancers has particularly highlighted the uncommon plasticity of differentiated parenchymal liver cells (that is, hepatocytes and cholangiocytes (also known as biliary epithelial cells)), the role of liver progenitor cells in malignant transformation, the importance of the tumour microenvironment and the molecular complexity of liver tumours. Whereas other reviews have focused on the landscape of genetic alterations that promote development and progression of primary liver cancers and the role of the tumour microenvironment, the crucial importance of the cellular origin of liver cancer has been much less explored. Therefore, in this Review, we emphasize the importance and complexity of the cellular origin in tumour initiation and progression, and attempt to integrate this aspect with recent discoveries in tumour genomics and the contribution of the disrupted hepatic microenvironment to liver carcinogenesis.

引用

页码：653 / 667

页数：15

共 145 条

[1] MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism [J].

Akita, Hirofumi ;

Marquardt, Jens U. ;

Durkin, Marian E. ;

Kitade, Mitsuteru ;

Seo, Daekwan ;

Conner, Elizabeth A. ;

Andersen, Jesper B. ;

Factor, Valentina M. ;

Thorgeirsson, Snorri S. .

CANCER RESEARCH, 2014, 74 (20) :5903-5913

[2] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[3] Molecular pathogenesis of intrahepatic cholangiocarcinoma [J].

Andersen, Jesper B. .

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, 2015, 22 (02) :101-113

[4] Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors [J].

Andersen, Jesper B. ;

Spee, Bart ;

Blechacz, Boris R. ;

Avital, Itzhak ;

Komuta, Mina ;

Barbour, Andrew ;

Conner, Elizabeth A. ;

Gillen, Matthew C. ;

Roskams, Tania ;

Roberts, Lewis R. ;

Factor, Valentina M. ;

Thorgeirsson, Snorri S. .

GASTROENTEROLOGY, 2012, 142 (04) :1021-U552

[5] Fibroblast Growth Factor Receptor 2 Tyrosine Kinase Fusions Define a Unique Molecular Subtype of Cholangiocarcinoma [J].

Arai, Yasuhito ;

Totoki, Yasushi ;

Hosoda, Fumie ;

Shirota, Tomoki ;

Hama, Natsuko ;

Nakamura, Hiromi ;

Ojima, Hidenori ;

Furuta, Koh ;

Shimada, Kazuaki ;

Okusaka, Takuji ;

Kosuge, Tomoo ;

Shibata, Tatsuhiro .

HEPATOLOGY, 2014, 59 (04) :1427-1434

[6] Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver [J].

Benhamouche, Samira ;

Curto, Marcello ;

Saotome, Ichiko ;

Gladden, Andrew B. ;

Liu, Ching-Hui ;

Giovannini, Marco ;

McClatchey, Andrea I. .

GENES & DEVELOPMENT, 2010, 24 (16) :1718-1730

[7] Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling [J].

Bird, Thomas G. ;

Lu, Wei-Yu ;

Boulter, Luke ;

Gordon-Keylock, Sabrina ;

Ridgway, Rachel A. ;

Williams, Michael J. ;

Taube, Jessica ;

Thomas, James A. ;

Wojtacha, Davina ;

Gambardella, Adriana ;

Sansom, Owen J. ;

Iredale, John P. ;

Forbes, Stuart J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (16) :6542-6547

[8] Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma [J].

Borad, Mitesh J. ;

Champion, Mia D. ;

Egan, Jan B. ;

Liang, Winnie S. ;

Fonseca, Rafael ;

Bryce, Alan H. ;

McCullough, Ann E. ;

Barrett, Michael T. ;

Hunt, Katherine ;

Patel, Maitray D. ;

Young, Scott W. ;

Collins, Joseph M. ;

Silva, Alvin C. ;

Condjella, Rachel M. ;

Block, Matthew ;

McWilliams, Robert R. ;

Lazaridis, Konstantinos N. ;

Klee, Eric W. ;

Bible, Keith C. ;

Harris, Pamela ;

Oliver, Gavin R. ;

Bhavsar, Jaysheel D. ;

Nair, Asha A. ;

Middha, Sumit ;

Asmann, Yan ;

Kocher, Jean-Pierre ;

Schahl, Kimberly ;

Kipp, Benjamin R. ;

Fritcher, Emily G. Barr ;

Baker, Angela ;

Aldrich, Jessica ;

Kurdoglu, Ahmet ;

Izatt, Tyler ;

Christoforides, Alexis ;

Cherni, Irene ;

Nasser, Sara ;

Reiman, Rebecca ;

Phillips, Lori ;

McDonald, Jackie ;

Adkins, Jonathan ;

Mastrian, Stephen D. ;

Placek, Pamela ;

Watanabe, Aprill T. ;

LoBello, Janine ;

Han, Haiyong ;

Von Hoff, Daniel ;

Craig, David W. ;

Stewart, A. Keith ;

Carpten, John D. .

PLOS GENETICS, 2014, 10 (02)

[9] Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease [J].

Boulter, Luke ;

Govaere, Olivier ;

Bird, Tom G. ;

Radulescu, Sorina ;

Ramachandran, Prakash ;

Pellicoro, Antonella ;

Ridgway, Rachel A. ;

Seo, Sang Soo ;

Spee, Bart ;

Van Rooijen, Nico ;

Sansom, Owen J. ;

Iredale, John P. ;

Lowell, Sally ;

Roskams, Tania ;

Forbes, Stuart J. .

NATURE MEDICINE, 2012, 18 (04) :572-579

[10] Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma [J].

Bridgewater, John ;

Galle, Peter R. ;

Khan, Shahid A. ;

Llovet, Josep M. ;

Park, Joong-Won ;

Patel, Tushar ;

Pawlik, Timothy M. ;

Gores, Gregory J. .

JOURNAL OF HEPATOLOGY, 2014, 60 (06) :1268-1289

← 1 2 3 4 5 6 7 8 9 10 →